{"id":"2dd1a865-2bc3-54aa-b04a-868261051b52","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-gut-glp1","predicate":"stimulates","statement":"Rebaudioside A concentration-dependently stimulated GLP-1 release in human HuTu-80 enteroendocrine cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"61d25594-53da-5259-9b38-b95ec1be05dd","mechanism_event_label":"An intestinal cell sensor can connect exposure to hormone release.","subject":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"object":{"id":"46731938-4c86-5195-b463-c14c70168dfc","slug":"human-hutu80-glp1-release","display_name":"Human HuTu-80 GLP-1 release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"61d25594-53da-5259-9b38-b95ec1be05dd","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-gut-glp1-event","event_type":"observed_relationship","label":"An intestinal cell sensor can connect exposure to hormone release.","description":"Rebaudioside A concentration-dependently stimulated GLP-1 release in human HuTu-80 enteroendocrine cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"46731938-4c86-5195-b463-c14c70168dfc","slug":"human-hutu80-glp1-release","display_name":"Human HuTu-80 GLP-1 release","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4853afc6-9eaa-547f-91d7-c4dd90082351","slug":"glp-1","display_name":"Glucagon-like peptide 1 / GLP-1","entity_type_key":"peptide"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human HuTu-80 cells, with separate mouse STC-1 experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The accessed abstract does not provide the tested concentration range; no oral human GLP-1 response is asserted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An intestinal cell sensor can connect exposure to hormone release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"449da126-dc4a-56ef-b588-0330e9ea3e0a","evidence_kind":"source_excerpt","locator":"Lines 258-264","start_line":258,"end_line":264,"excerpt":"## stevia-gut-glp1\nAn intestinal cell sensor can connect exposure to hormone release.\nRebaudioside A concentration-dependently stimulated GLP-1 release in human HuTu-80 enteroendocrine cells.\nModel: Human HuTu-80 cells, with separate mouse STC-1 experiments.\nLimitations: The accessed abstract does not provide the tested concentration range; no oral human GLP-1 response is asserted.\nEvidence access: Primary abstract\nRebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e","model_system":"Human HuTu-80 cells, with separate mouse STC-1 experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}