{"id":"6582bec1-f506-51b9-822c-302e6ff7dbe6","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-human-timing","predicate":"delays_relative_to_stevioside","statement":"Median plasma steviol-glucuronide peak times were 12 hours after rebaudioside A and 8 hours after stevioside; elimination half-lives were approximately 14 hours.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9e6b1d92-8f10-5c3e-b060-5324fc20dc34","mechanism_event_label":"An oral sweet taste and a circulating metabolite peak occur on different timelines.","subject":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"object":{"id":"b9b56691-cd29-5279-8753-6389de8364f6","slug":"human-steviol-glucuronide-peak-time","display_name":"Human steviol-glucuronide time to peak","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9e6b1d92-8f10-5c3e-b060-5324fc20dc34","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-human-timing-event","event_type":"observed_relationship","label":"An oral sweet taste and a circulating metabolite peak occur on different timelines.","description":"Median plasma steviol-glucuronide peak times were 12 hours after rebaudioside A and 8 hours after stevioside; elimination half-lives were approximately 14 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b9b56691-cd29-5279-8753-6389de8364f6","slug":"human-steviol-glucuronide-peak-time","display_name":"Human steviol-glucuronide time to peak","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f008b74d-164b-5663-a72e-04a48fe7a8fb","slug":"steviol-glucuronide","display_name":"Steviol glucuronide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"fe6ad129-03ef-56c0-9a09-52ba2a60cabb","evidence_kind":"source_excerpt","locator":"Lines 82-88","start_line":82,"end_line":88,"excerpt":"## stevia-human-timing\nAn oral sweet taste and a circulating metabolite peak occur on different timelines.\nMedian plasma steviol-glucuronide peak times were 12 hours after rebaudioside A and 8 hours after stevioside; elimination half-lives were approximately 14 hours.\nModel: Same crossover study in healthy men.\nLimitations: Group medians do not predict one person or another formulation.\nEvidence access: Primary abstract\nPharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555578/ · DOI 10.1016/j.fct.2008.04.041","model_system":"Same crossover study in healthy men.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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