{"id":"5a01b80b-4232-544f-b8d1-a4e133a7143d","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-microbial-reba","predicate":"converted_to","statement":"Rebaudioside A was completely hydrolyzed to steviol in 24 hours in the same human fecal culture experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"87c7b8a2-0553-5126-8da4-711ca7efd689","mechanism_event_label":"Closely related glycosides can reach a shared metabolite at different rates.","subject":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"object":{"id":"8ba32fe6-183f-5cd5-b386-02e6440e78a0","slug":"steviol","display_name":"Steviol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"87c7b8a2-0553-5126-8da4-711ca7efd689","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-microbial-reba-event","event_type":"observed_relationship","label":"Closely related glycosides can reach a shared metabolite at different rates.","description":"Rebaudioside A was completely hydrolyzed to steviol in 24 hours in the same human fecal culture experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8ba32fe6-183f-5cd5-b386-02e6440e78a0","slug":"steviol","display_name":"Steviol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Anaerobic fecal cultures; isolated bacterial groups.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rate differences depend on culture conditions and microbial composition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Closely related glycosides can reach a shared metabolite at different rates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f1eb9a5a-383d-5f74-ba2a-36c35d1eafd5","evidence_kind":"source_excerpt","locator":"Lines 26-32","start_line":26,"end_line":32,"excerpt":"## stevia-microbial-reba\nClosely related glycosides can reach a shared metabolite at different rates.\nRebaudioside A was completely hydrolyzed to steviol in 24 hours in the same human fecal culture experiments.\nModel: Anaerobic fecal cultures; isolated bacterial groups.\nLimitations: Rate differences depend on culture conditions and microbial composition.\nEvidence access: Primary abstract\nMetabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619","model_system":"Anaerobic fecal cultures; isolated bacterial groups.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}