Component
Human plasma rebaudioside A
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Following a single 3 g oral dose, rebaudioside A was detected in plasma as early as one hour in nearly all participants; steviol and its glucuronide peaked at 19.5 hours.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Thirty adults with type 2 diabetes; open-label randomized placebo crossover; metformin or no therapy.
- limitations
- This does not establish the fraction absorbed intact or justify a blanket statement that glycosides are never absorbed.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- Some intact parent compound can be detected after a large dose.
- primary_references
- Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057030/ · DOI 10.1007/s13318-022-00792-7
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 90–96
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Thirty adults with type 2 diabetes; open-label randomized placebo crossover; metformin or no therapy. · source_derived_draft · unverified_draft
## stevia-intact-reba Some intact parent compound can be detected after a large dose. Following a single 3 g oral dose, rebaudioside A was detected in plasma as early as one hour in nearly all participants; steviol and its glucuronide peaked at 19.5 hours. Model: Thirty adults with type 2 diabetes; open-label randomized placebo crossover; metformin or no therapy. Limitations: This does not establish the fraction absorbed intact or justify a blanket statement that glycosides are never absorbed. Evidence access: Primary abstract Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057030/ · DOI 10.1007/s13318-022-00792-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.