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the same paper reports reduced KATP conductance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The causal chain from nucleotide change to conductance was proposed rather than isolated by every possible intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Energy state may connect a glycoside response to potassium-channel closure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18435771/ · DOI 10.1111/j.1463-1326.2008.00864.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"84709f7d-f146-5d35-b831-ac3a159003a8","evidence_kind":"source_excerpt","locator":"Lines 242-248","start_line":242,"end_line":248,"excerpt":"## stevia-reba-atp\nEnergy state may connect a glycoside response to potassium-channel closure.\nRebaudioside A at 1 nM increased the ATP/ADP ratio at 16.7 mM glucose while not changing measured cAMP.\nModel: Mouse islet nucleotide assays; the same paper reports reduced KATP conductance.\nLimitations: The causal chain from nucleotide change to conductance was proposed rather than isolated by every possible intervention.\nEvidence access: Primary abstract\nRebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18435771/ · DOI 10.1111/j.1463-1326.2008.00864.x","model_system":"Mouse islet nucleotide assays; the same paper reports reduced KATP conductance.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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