{"id":"6da1e47f-5d72-52cc-b7ad-3737577f4405","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-gut-gaba","predicate":"modulates_in_assay","statement":"The study reported that GABA and 6-methoxyflavanone can modulate rebaudioside-A-dependent GLP-1 release.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9a77cf40-329d-58c5-91e3-10c940a8a8d3","mechanism_event_label":"Other dietary compounds may change a response at a shared signaling system.","subject":{"id":"d5b98fa8-0612-5a5a-aa3c-6cfd8ff88867","slug":"gaba","display_name":"Gamma-aminobutyric acid","entity_type_key":"small_molecule"},"object":{"id":"b743f100-a76b-568e-94df-daf0a95e494a","slug":"enteroendocrine-reba-glp1-modulation-assay","display_name":"Rebaudioside-A GLP-1 modulation assay, cell-specific assignment unresolved","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9a77cf40-329d-58c5-91e3-10c940a8a8d3","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-gut-gaba-event","event_type":"observed_relationship","label":"Other dietary compounds may change a response at a shared signaling system.","description":"The study reported that GABA and 6-methoxyflavanone can modulate rebaudioside-A-dependent GLP-1 release.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d5b98fa8-0612-5a5a-aa3c-6cfd8ff88867","slug":"gaba","display_name":"Gamma-aminobutyric acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b743f100-a76b-568e-94df-daf0a95e494a","slug":"enteroendocrine-reba-glp1-modulation-assay","display_name":"Rebaudioside-A GLP-1 modulation assay, cell-specific assignment unresolved","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"21c73b8b-9c7d-53e0-83bc-1da4e631133b","slug":"6-methoxyflavanone","display_name":"6-Methoxyflavanone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse and human enteroendocrine signaling study; direction and cell-specific exposure unresolved in the accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is recorded only as context-dependent modulation; no direction, effective dietary dose or supplement synergy is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Other dietary compounds may change a response at a shared signaling system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c45217ab-d4c8-596c-9185-bf3f85c5f9f5","evidence_kind":"source_excerpt","locator":"Lines 282-288","start_line":282,"end_line":288,"excerpt":"## stevia-gut-gaba\nOther dietary compounds may change a response at a shared signaling system.\nThe study reported that GABA and 6-methoxyflavanone can modulate rebaudioside-A-dependent GLP-1 release.\nModel: Mouse and human enteroendocrine signaling study; direction and cell-specific exposure unresolved in the accessed abstract.\nLimitations: This is recorded only as context-dependent modulation; no direction, effective dietary dose or supplement synergy is inferred.\nEvidence access: Primary abstract\nRebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e","model_system":"Mouse and human enteroendocrine signaling study; direction and cell-specific exposure unresolved in the accessed abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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