Component
Human bitter taste receptor / TAS2R4
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Inhibitor experiments in human HuTu-80 cells supported TAS2R4 involvement in rebaudioside-A-evoked GLP-1 release.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human cell-line pharmacology; sweet-signaling inhibition did not explain the response.
- limitations
- Pharmacological inhibition does not establish exclusive receptor involvement or in vivo necessity.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- A bitter receptor participates in a gut-hormone response.
- primary_references
- Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 266–272
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human cell-line pharmacology; sweet-signaling inhibition did not explain the response. · source_derived_draft · unverified_draft
## stevia-gut-tas2r4 A bitter receptor participates in a gut-hormone response. Inhibitor experiments in human HuTu-80 cells supported TAS2R4 involvement in rebaudioside-A-evoked GLP-1 release. Model: Human cell-line pharmacology; sweet-signaling inhibition did not explain the response. Limitations: Pharmacological inhibition does not establish exclusive receptor involvement or in vivo necessity. Evidence access: Primary abstract Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e
Complete structured claim and evidence
What acts on it
Screening 25 human bitter taste receptors identified TAS2R4 among the receptors mediating steviol-glycoside bitter off-taste.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human receptor-expression assays and sensory studies.
- limitations
- Individual glycosides differ in receptor potency; this is not a claim that every glycoside is equally bitter.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- The sweetener can also engage a bitter receptor.
- primary_references
- Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 154–160
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human receptor-expression assays and sensory studies. · source_derived_draft · unverified_draft
## stevia-bitter4 The sweetener can also engage a bitter receptor. Screening 25 human bitter taste receptors identified TAS2R4 among the receptors mediating steviol-glycoside bitter off-taste. Model: Human receptor-expression assays and sensory studies. Limitations: Individual glycosides differ in receptor potency; this is not a claim that every glycoside is equally bitter. Evidence access: Primary abstract Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.