{"id":"0748d080-7e6e-59a8-84d1-ece0ec7d79cd","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-bitter4","predicate":"activates","statement":"Screening 25 human bitter taste receptors identified TAS2R4 among the receptors mediating steviol-glycoside bitter off-taste.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"76ebd098-0d96-59aa-bfb4-96d4db28f95a","mechanism_event_label":"The sweetener can also engage a bitter receptor.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"68bb2641-602b-5462-bbb0-96cc455be293","slug":"tas2r4","display_name":"Human bitter taste receptor / TAS2R4","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"76ebd098-0d96-59aa-bfb4-96d4db28f95a","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-bitter4-event","event_type":"observed_relationship","label":"The sweetener can also engage a bitter receptor.","description":"Screening 25 human bitter taste receptors identified TAS2R4 among the receptors mediating steviol-glycoside bitter off-taste.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"68bb2641-602b-5462-bbb0-96cc455be293","slug":"tas2r4","display_name":"Human bitter taste receptor / TAS2R4","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human receptor-expression assays and sensory studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Individual glycosides differ in receptor potency; this is not a claim that every glycoside is equally bitter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The sweetener can also engage a bitter receptor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"27a2d9de-aa1b-5f63-9ff7-e4bb6ee671a5","evidence_kind":"source_excerpt","locator":"Lines 154-160","start_line":154,"end_line":160,"excerpt":"## stevia-bitter4\nThe sweetener can also engage a bitter receptor.\nScreening 25 human bitter taste receptors identified TAS2R4 among the receptors mediating steviol-glycoside bitter off-taste.\nModel: Human receptor-expression assays and sensory studies.\nLimitations: Individual glycosides differ in receptor potency; this is not a claim that every glycoside is equally bitter.\nEvidence access: Primary abstract\nHuman psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n","model_system":"Human receptor-expression assays and sensory studies.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}