Component

Human sweet taste receptor TAS1R2/TAS1R3

Context-specific entity; species, compartment and exposure are stated on each claim.

8 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Human sensory and receptor-expression experiments examined stevioside sweet responses through TAS1R2/TAS1R3; falling sweetness at high concentration was not attributed to allosteric suppression of that receptor.

    Stevioside → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human sensory testing and cell-based functional receptor assays.
    limitations
    The sensory outcome does not establish pancreatic insulin release or systemic glucose lowering.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Sweetness perception can change without direct inhibition of the sweet receptor.
    primary_references
    Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 146–152

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human sensory testing and cell-based functional receptor assays. · source_derived_draft · unverified_draft

    ## stevia-sweet-receptor Sweetness perception can change without direct inhibition of the sweet receptor. Human sensory and receptor-expression experiments examined stevioside sweet responses through TAS1R2/TAS1R3; falling sweetness at high concentration was not attributed to allosteric suppression of that receptor. Model: Human sensory testing and cell-based functional receptor assays. Limitations: The sensory outcome does not establish pancreatic insulin release or systemic glucose lowering. Evidence access: Primary abstract Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n
    Complete structured claim and evidence

  2. Human T1R2/T1R3 responded to aspartame in heterologous receptor assays.

    Aspartame → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary article response panel and abstract
    experimental_model
    Human receptor coexpression, aspartame response panel.
    limitations
    Receptor activation is not a quantified human insulin response.
    nutrient_topic
    Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Aspartame
    plain_language
    The intact sweetener has a receptor action before its metabolites are considered.
    primary_references
    Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199

    Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20) · lines 162–168

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human receptor coexpression, aspartame response panel. · source_derived_draft · unverified_draft

    ## aspartame-human-sweet-receptor The intact sweetener has a receptor action before its metabolites are considered. Human T1R2/T1R3 responded to aspartame in heterologous receptor assays. Model: Human receptor coexpression, aspartame response panel. Limitations: Receptor activation is not a quantified human insulin response. Evidence access: Primary article response panel and abstract Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199
    Complete structured claim and evidence

  3. Coapplied Glu-Asp attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.

    L-Glutamyl-L-aspartate / Glu-Asp → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    dose
    Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG
    duration
    120-second fluorescence acquisition; imaging at 30 seconds
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Human TAS1R2/TAS1R3 in Flp-In 293 cells
    exposure_scope
    Nutrient and peptide modulation of human sweet receptor
    limitations
    Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Human TAS1R2/TAS1R3 in Flp-In 293 cells
    plain_language
    Coapplied Glu-Asp attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.
    primary_references
    Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030
    route
    In vitro coapplication
    tissue
    Sweet-receptor calcium signaling

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 103–113

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 in Flp-In 293 cells · source_derived_draft · unverified_draft

    ## sucrose-gluasp-receptor Coapplied Glu-Asp attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3. Model/species: Human TAS1R2/TAS1R3 in Flp-In 293 cells Tissue: Sweet-receptor calcium signaling Exposure: Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG Route: In vitro coapplication Duration: 120-second fluorescence acquisition; imaging at 30 seconds Exposure scope: Nutrient and peptide modulation of human sweet receptor Limits: Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels. Reference: Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

  4. Coapplied Glu-Glu attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.

    L-Glutamyl-L-glutamate / Glu-Glu → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    dose
    Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG
    duration
    120-second fluorescence acquisition; imaging at 30 seconds
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Human TAS1R2/TAS1R3 in Flp-In 293 cells
    exposure_scope
    Nutrient and peptide modulation of human sweet receptor
    limitations
    Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Human TAS1R2/TAS1R3 in Flp-In 293 cells
    plain_language
    Coapplied Glu-Glu attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.
    primary_references
    Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030
    route
    In vitro coapplication
    tissue
    Sweet-receptor calcium signaling

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 91–101

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 in Flp-In 293 cells · source_derived_draft · unverified_draft

    ## sucrose-gluglu-receptor Coapplied Glu-Glu attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3. Model/species: Human TAS1R2/TAS1R3 in Flp-In 293 cells Tissue: Sweet-receptor calcium signaling Exposure: Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG Route: In vitro coapplication Duration: 120-second fluorescence acquisition; imaging at 30 seconds Exposure scope: Nutrient and peptide modulation of human sweet receptor Limits: Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels. Reference: Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

  5. Lactisole inhibited the sucrose-evoked response of expressed human TAS1R2/TAS1R3.

    Lactisole → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mM sucrose with or without 1.25 mM lactisole
    duration
    Acute calcium response
    evidence_access
    Selected primary full-text sections inspected via indexed PMC page; local XML has abstract only.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells
    exposure_scope
    Human receptor in an expression system
    limitations
    Engineered coupling and high assay concentration do not measure human dietary absorption. Rat lactisole sensitivity differs. Selected full-text sections inspected; archived XML is abstract only.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells
    plain_language
    Lactisole inhibited the sucrose-evoked response of expressed human TAS1R2/TAS1R3.
    primary_references
    Human receptors for sweet and umami taste. (2002). https://pubmed.ncbi.nlm.nih.gov/11917125/ DOI: 10.1073/pnas.072090199
    route
    In vitro receptor stimulation
    tissue
    Recombinant sweet-receptor calcium-response assay

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 67–77

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells · source_derived_draft · unverified_draft

    ## sucrose-lactisole-receptor Lactisole inhibited the sucrose-evoked response of expressed human TAS1R2/TAS1R3. Model/species: Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells Tissue: Recombinant sweet-receptor calcium-response assay Exposure: 300 mM sucrose with or without 1.25 mM lactisole Route: In vitro receptor stimulation Duration: Acute calcium response Exposure scope: Human receptor in an expression system Limits: Engineered coupling and high assay concentration do not measure human dietary absorption. Rat lactisole sensitivity differs. Selected full-text sections inspected; archived XML is abstract only. Reference: Human receptors for sweet and umami taste. (2002). https://pubmed.ncbi.nlm.nih.gov/11917125/ DOI: 10.1073/pnas.072090199 Access: Selected primary full-text sections inspected via indexed PMC page; local XML has abstract only.
    Complete structured claim and evidence

  6. Coapplied MSG attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.

    Monosodium L-glutamate → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    dose
    Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG
    duration
    120-second fluorescence acquisition; imaging at 30 seconds
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Human TAS1R2/TAS1R3 in Flp-In 293 cells
    exposure_scope
    Nutrient and peptide modulation of human sweet receptor
    limitations
    Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Human TAS1R2/TAS1R3 in Flp-In 293 cells
    plain_language
    Coapplied MSG attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.
    primary_references
    Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030
    route
    In vitro coapplication
    tissue
    Sweet-receptor calcium signaling

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 79–89

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 in Flp-In 293 cells · source_derived_draft · unverified_draft

    ## sucrose-msg-receptor Coapplied MSG attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3. Model/species: Human TAS1R2/TAS1R3 in Flp-In 293 cells Tissue: Sweet-receptor calcium signaling Exposure: Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG Route: In vitro coapplication Duration: 120-second fluorescence acquisition; imaging at 30 seconds Exposure scope: Nutrient and peptide modulation of human sweet receptor Limits: Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels. Reference: Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

  7. Sucrose elicited a calcium response in cells coexpressing human TAS1R2 and TAS1R3, but not either subunit alone.

    Sucrose → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mM sucrose with or without 1.25 mM lactisole
    duration
    Acute calcium response
    evidence_access
    Selected primary full-text sections inspected via indexed PMC page; local XML has abstract only.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells
    exposure_scope
    Human receptor in an expression system
    limitations
    Engineered coupling and high assay concentration do not measure human dietary absorption. Rat lactisole sensitivity differs. Selected full-text sections inspected; archived XML is abstract only.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells
    plain_language
    Sucrose elicited a calcium response in cells coexpressing human TAS1R2 and TAS1R3, but not either subunit alone.
    primary_references
    Human receptors for sweet and umami taste. (2002). https://pubmed.ncbi.nlm.nih.gov/11917125/ DOI: 10.1073/pnas.072090199
    route
    In vitro receptor stimulation
    tissue
    Recombinant sweet-receptor calcium-response assay

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 55–65

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells · source_derived_draft · unverified_draft

    ## sucrose-sweet-receptor Sucrose elicited a calcium response in cells coexpressing human TAS1R2 and TAS1R3, but not either subunit alone. Model/species: Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells Tissue: Recombinant sweet-receptor calcium-response assay Exposure: 300 mM sucrose with or without 1.25 mM lactisole Route: In vitro receptor stimulation Duration: Acute calcium response Exposure scope: Human receptor in an expression system Limits: Engineered coupling and high assay concentration do not measure human dietary absorption. Rat lactisole sensitivity differs. Selected full-text sections inspected; archived XML is abstract only. Reference: Human receptors for sweet and umami taste. (2002). https://pubmed.ncbi.nlm.nih.gov/11917125/ DOI: 10.1073/pnas.072090199 Access: Selected primary full-text sections inspected via indexed PMC page; local XML has abstract only.
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Mutagenesis identified eleven T1R2 residues important for aspartame responses: S40, Y103, D142, S144, S165, S168, Y215, D278, E302, D307 and R383.

    Human taste receptor TAS1R2 → Aspartame source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human receptor mutants and homology models.
    limitations
    Loss of response can affect binding, folding or activation; not every residue is necessarily a direct contact.
    nutrient_topic
    Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Aspartame
    plain_language
    Small changes in the sensor can alter recognition.
    primary_references
    Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26377607/ · DOI 10.1093/chemse/bjv045

    Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20) · lines 170–176

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human receptor mutants and homology models. · source_derived_draft · unverified_draft

    ## aspartame-binding-residues Small changes in the sensor can alter recognition. Mutagenesis identified eleven T1R2 residues important for aspartame responses: S40, Y103, D142, S144, S165, S168, Y215, D278, E302, D307 and R383. Model: Human receptor mutants and homology models. Limitations: Loss of response can affect binding, folding or activation; not every residue is necessarily a direct contact. Evidence access: Primary abstract Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26377607/ · DOI 10.1093/chemse/bjv045
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards