{"id":"07d50774-7fe1-5227-9af9-71ccbd7e86d8","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-sweet-receptor","predicate":"engages","statement":"Human sensory and receptor-expression experiments examined stevioside sweet responses through TAS1R2/TAS1R3; falling sweetness at high concentration was not attributed to allosteric suppression of that receptor.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a0fb18dc-1aa8-5fc2-bc92-79fe612ca3c1","mechanism_event_label":"Sweetness perception can change without direct inhibition of the sweet receptor.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"2eca6132-b441-5473-98bb-6759c0b2a5fc","slug":"human-tas1r2-tas1r3","display_name":"Human sweet taste receptor TAS1R2/TAS1R3","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"a0fb18dc-1aa8-5fc2-bc92-79fe612ca3c1","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-sweet-receptor-event","event_type":"observed_relationship","label":"Sweetness perception can change without direct inhibition of the sweet receptor.","description":"Human sensory and receptor-expression experiments examined stevioside sweet responses through TAS1R2/TAS1R3; falling sweetness at high concentration was not attributed to allosteric suppression of that receptor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2eca6132-b441-5473-98bb-6759c0b2a5fc","slug":"human-tas1r2-tas1r3","display_name":"Human sweet taste receptor TAS1R2/TAS1R3","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human sensory testing and cell-based functional receptor assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The sensory outcome does not establish pancreatic insulin release or systemic glucose lowering.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Sweetness perception can change without direct inhibition of the sweet receptor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d0e1344d-1bd1-5fd8-a3e8-5e2c2bc0e092","evidence_kind":"source_excerpt","locator":"Lines 146-152","start_line":146,"end_line":152,"excerpt":"## stevia-sweet-receptor\nSweetness perception can change without direct inhibition of the sweet receptor.\nHuman sensory and receptor-expression experiments examined stevioside sweet responses through TAS1R2/TAS1R3; falling sweetness at high concentration was not attributed to allosteric suppression of that receptor.\nModel: Human sensory testing and cell-based functional receptor assays.\nLimitations: The sensory outcome does not establish pancreatic insulin release or systemic glucose lowering.\nEvidence access: Primary abstract\nHuman psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n","model_system":"Human sensory testing and cell-based functional receptor assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}