Component
L-Glutamyl-L-glutamate / Glu-Glu
Alpha-linked glutamyl dipeptide tested in the human sweet-receptor expression assay; not gamma-glutamylcysteine.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Coapplied Glu-Glu attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.
Experimental context and source evidence
- dose
- Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG
- duration
- 120-second fluorescence acquisition; imaging at 30 seconds
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Human TAS1R2/TAS1R3 in Flp-In 293 cells
- exposure_scope
- Nutrient and peptide modulation of human sweet receptor
- limitations
- Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels.
- nutrient_topic
- Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
- organism
- Human TAS1R2/TAS1R3 in Flp-In 293 cells
- plain_language
- Coapplied Glu-Glu attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3.
- primary_references
- Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030
- route
- In vitro coapplication
- tissue
- Sweet-receptor calcium signaling
Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 91–101
Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 in Flp-In 293 cells · source_derived_draft · unverified_draft
## sucrose-gluglu-receptor Coapplied Glu-Glu attenuated the sucrose-evoked calcium response in cells expressing human TAS1R2/TAS1R3. Model/species: Human TAS1R2/TAS1R3 in Flp-In 293 cells Tissue: Sweet-receptor calcium signaling Exposure: Sucrose concentration series up to 150 mM; MSG or Glu-Glu/Glu-Asp concentration series; mutant imaging used 100 mM sucrose with 1 mM Glu-Glu or 50 mM MSG Route: In vitro coapplication Duration: 120-second fluorescence acquisition; imaging at 30 seconds Exposure scope: Nutrient and peptide modulation of human sweet receptor Limits: Cellular response, not a direct binding assay or a demonstration that every food tastes less sweet. pH/osmolarity controls and agonist-specific responses limit interpretation. Doses differ among panels. Reference: Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. (2015). https://pubmed.ncbi.nlm.nih.gov/25853419/ DOI: 10.1371/journal.pone.0124030 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.