{"id":"1eee27f6-5975-5a85-92c4-672f35f0e7ce","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-human-sweet-receptor","predicate":"activates","statement":"Human T1R2/T1R3 responded to aspartame in heterologous receptor assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"82e2099d-fef5-5ae2-8745-612db08fcaba","mechanism_event_label":"The intact sweetener has a receptor action before its metabolites are considered.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"2eca6132-b441-5473-98bb-6759c0b2a5fc","slug":"human-tas1r2-tas1r3","display_name":"Human sweet taste receptor TAS1R2/TAS1R3","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"82e2099d-fef5-5ae2-8745-612db08fcaba","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-human-sweet-receptor-event","event_type":"observed_relationship","label":"The intact sweetener has a receptor action before its metabolites are considered.","description":"Human T1R2/T1R3 responded to aspartame in heterologous receptor assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2eca6132-b441-5473-98bb-6759c0b2a5fc","slug":"human-tas1r2-tas1r3","display_name":"Human sweet taste receptor TAS1R2/TAS1R3","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"09713aab-d5e3-589c-83c2-95d3989efd62","slug":"tas1r2","display_name":"Human taste receptor TAS1R2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7ab6f209-2089-5008-b64e-64f8db8c7771","slug":"tas1r3","display_name":"Human taste receptor TAS1R3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary article response panel and abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human receptor coexpression, aspartame response panel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Receptor activation is not a quantified human insulin response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The intact sweetener has a receptor action before its metabolites are considered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"17cb72e5-220b-57e6-ba3b-0d57d8aef614","evidence_kind":"source_excerpt","locator":"Lines 162-168","start_line":162,"end_line":168,"excerpt":"## aspartame-human-sweet-receptor\nThe intact sweetener has a receptor action before its metabolites are considered.\nHuman T1R2/T1R3 responded to aspartame in heterologous receptor assays.\nModel: Human receptor coexpression, aspartame response panel.\nLimitations: Receptor activation is not a quantified human insulin response.\nEvidence access: Primary article response panel and abstract\nHuman receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199","model_system":"Human receptor coexpression, aspartame response panel.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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