Component

Lactisole

Experimental sweet-taste antagonist; not an approved metabolic treatment in this collection.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Adding lactisole to sucrose did not significantly change postprandial plasma CCK.

    Lactisole → Human plasma cholecystokinin response source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions
    duration
    120 minutes; breakfast at 2 hours
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    27 healthy men in randomized single-blinded crossover
    exposure_scope
    Sucrose and taste antagonist
    limitations
    Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    27 healthy men in randomized single-blinded crossover
    plain_language
    Adding lactisole to sucrose did not significantly change postprandial plasma CCK.
    primary_references
    Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133
    route
    Oral test drink after overnight fast
    tissue
    Subsequent food intake and peripheral hormone measurements

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 139–149

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 27 healthy men in randomized single-blinded crossover · source_derived_draft · unverified_draft

    ## sucrose-lactisole-cck-null Adding lactisole to sucrose did not significantly change postprandial plasma CCK. Model/species: 27 healthy men in randomized single-blinded crossover Tissue: Subsequent food intake and peripheral hormone measurements Exposure: 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions Route: Oral test drink after overnight fast Duration: 120 minutes; breakfast at 2 hours Exposure scope: Sucrose and taste antagonist Limits: Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome. Reference: Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

  2. Adding lactisole to sucrose did not significantly change postprandial plasma ghrelin.

    Lactisole → Human postprandial plasma ghrelin response source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions
    duration
    120 minutes; breakfast at 2 hours
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    27 healthy men in randomized single-blinded crossover
    exposure_scope
    Sucrose and taste antagonist
    limitations
    Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    27 healthy men in randomized single-blinded crossover
    plain_language
    Adding lactisole to sucrose did not significantly change postprandial plasma ghrelin.
    primary_references
    Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133
    route
    Oral test drink after overnight fast
    tissue
    Subsequent food intake and peripheral hormone measurements

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 151–161

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 27 healthy men in randomized single-blinded crossover · source_derived_draft · unverified_draft

    ## sucrose-lactisole-ghrelin-null Adding lactisole to sucrose did not significantly change postprandial plasma ghrelin. Model/species: 27 healthy men in randomized single-blinded crossover Tissue: Subsequent food intake and peripheral hormone measurements Exposure: 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions Route: Oral test drink after overnight fast Duration: 120 minutes; breakfast at 2 hours Exposure scope: Sucrose and taste antagonist Limits: Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome. Reference: Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

  3. Adding 60 ppm lactisole to the sucrose drink increased subsequent breakfast energy intake by 12.9 +/- 5.8% in the male crossover study.

    Lactisole → Human subsequent meal energy intake after sucrose with lactisole source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions
    duration
    120 minutes; breakfast at 2 hours
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    27 healthy men in randomized single-blinded crossover
    exposure_scope
    Sucrose and taste antagonist
    limitations
    Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    27 healthy men in randomized single-blinded crossover
    plain_language
    Adding 60 ppm lactisole to the sucrose drink increased subsequent breakfast energy intake by 12.9 +/- 5.8% in the male crossover study.
    primary_references
    Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133
    route
    Oral test drink after overnight fast
    tissue
    Subsequent food intake and peripheral hormone measurements

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 115–125

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 27 healthy men in randomized single-blinded crossover · source_derived_draft · unverified_draft

    ## sucrose-lactisole-intake Adding 60 ppm lactisole to the sucrose drink increased subsequent breakfast energy intake by 12.9 +/- 5.8% in the male crossover study. Model/species: 27 healthy men in randomized single-blinded crossover Tissue: Subsequent food intake and peripheral hormone measurements Exposure: 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions Route: Oral test drink after overnight fast Duration: 120 minutes; breakfast at 2 hours Exposure scope: Sucrose and taste antagonist Limits: Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome. Reference: Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

  4. Lactisole inhibited the sucrose-evoked response of expressed human TAS1R2/TAS1R3.

    Lactisole → Human sweet taste receptor TAS1R2/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mM sucrose with or without 1.25 mM lactisole
    duration
    Acute calcium response
    evidence_access
    Selected primary full-text sections inspected via indexed PMC page; local XML has abstract only.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells
    exposure_scope
    Human receptor in an expression system
    limitations
    Engineered coupling and high assay concentration do not measure human dietary absorption. Rat lactisole sensitivity differs. Selected full-text sections inspected; archived XML is abstract only.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells
    plain_language
    Lactisole inhibited the sucrose-evoked response of expressed human TAS1R2/TAS1R3.
    primary_references
    Human receptors for sweet and umami taste. (2002). https://pubmed.ncbi.nlm.nih.gov/11917125/ DOI: 10.1073/pnas.072090199
    route
    In vitro receptor stimulation
    tissue
    Recombinant sweet-receptor calcium-response assay

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 67–77

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells · source_derived_draft · unverified_draft

    ## sucrose-lactisole-receptor Lactisole inhibited the sucrose-evoked response of expressed human TAS1R2/TAS1R3. Model/species: Human TAS1R2/TAS1R3 coexpressed with engineered G-alpha15 in HEK-derived cells Tissue: Recombinant sweet-receptor calcium-response assay Exposure: 300 mM sucrose with or without 1.25 mM lactisole Route: In vitro receptor stimulation Duration: Acute calcium response Exposure scope: Human receptor in an expression system Limits: Engineered coupling and high assay concentration do not measure human dietary absorption. Rat lactisole sensitivity differs. Selected full-text sections inspected; archived XML is abstract only. Reference: Human receptors for sweet and umami taste. (2002). https://pubmed.ncbi.nlm.nih.gov/11917125/ DOI: 10.1073/pnas.072090199 Access: Selected primary full-text sections inspected via indexed PMC page; local XML has abstract only.
    Complete structured claim and evidence

  5. Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.

    Lactisole → Human postprandial plasma serotonin response source_derived_draftungraded
    Experimental context and source evidence
    dose
    300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions
    duration
    120 minutes; breakfast at 2 hours
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    27 healthy men in randomized single-blinded crossover
    exposure_scope
    Sucrose and taste antagonist
    limitations
    Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    27 healthy men in randomized single-blinded crossover
    plain_language
    Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.
    primary_references
    Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133
    route
    Oral test drink after overnight fast
    tissue
    Subsequent food intake and peripheral hormone measurements

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 127–137

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 27 healthy men in randomized single-blinded crossover · source_derived_draft · unverified_draft

    ## sucrose-lactisole-serotonin Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone. Model/species: 27 healthy men in randomized single-blinded crossover Tissue: Subsequent food intake and peripheral hormone measurements Exposure: 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions Route: Oral test drink after overnight fast Duration: 120 minutes; breakfast at 2 hours Exposure scope: Sucrose and taste antagonist Limits: Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome. Reference: Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards