{"id":"041c3f03-8634-588c-b221-4d0402d74281","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-lactisole-serotonin","predicate":"reduces_after_sucrose","statement":"Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"84e32c9e-fdba-547c-bf66-cc73c65f519d","mechanism_event_label":"Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.","subject":{"id":"7ccdbbaf-dfdc-5e35-bcd7-a360b0db78e1","slug":"lactisole","display_name":"Lactisole","entity_type_key":"small_molecule"},"object":{"id":"a9cd1253-fd2e-55e4-b2d6-356a3fb15ba1","slug":"human-plasma-serotonin-response","display_name":"Human postprandial plasma serotonin response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"84e32c9e-fdba-547c-bf66-cc73c65f519d","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-lactisole-serotonin-event","event_type":"observed_relationship","label":"Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.","description":"Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7ccdbbaf-dfdc-5e35-bcd7-a360b0db78e1","slug":"lactisole","display_name":"Lactisole","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a9cd1253-fd2e-55e4-b2d6-356a3fb15ba1","slug":"human-plasma-serotonin-response","display_name":"Human postprandial plasma serotonin response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fef9ecc3-7c04-553c-a207-d91e38a2665a","slug":"serotonin","display_name":"Serotonin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"120 minutes; breakfast at 2 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"27 healthy men in randomized single-blinded crossover","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Sucrose and taste antagonist","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"27 healthy men in randomized single-blinded crossover","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral test drink after overnight fast","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Subsequent food intake and peripheral hormone measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ceb37962-366a-5fca-9280-28f60ef18641","evidence_kind":"source_excerpt","locator":"Lines 127-137","start_line":127,"end_line":137,"excerpt":"## sucrose-lactisole-serotonin\nAdding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.\nModel/species: 27 healthy men in randomized single-blinded crossover\nTissue: Subsequent food intake and peripheral hormone measurements\nExposure: 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions\nRoute: Oral test drink after overnight fast\nDuration: 120 minutes; breakfast at 2 hours\nExposure scope: Sucrose and taste antagonist\nLimits: Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.\nReference: Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"27 healthy men in randomized single-blinded crossover","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}