Component
Human postprandial plasma serotonin response
Species, exposure, manipulation and limitations are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.
Experimental context and source evidence
- dose
- 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions
- duration
- 120 minutes; breakfast at 2 hours
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- 27 healthy men in randomized single-blinded crossover
- exposure_scope
- Sucrose and taste antagonist
- limitations
- Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome.
- nutrient_topic
- Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
- organism
- 27 healthy men in randomized single-blinded crossover
- plain_language
- Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone.
- primary_references
- Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133
- route
- Oral test drink after overnight fast
- tissue
- Subsequent food intake and peripheral hormone measurements
Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 127–137
Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 27 healthy men in randomized single-blinded crossover · source_derived_draft · unverified_draft
## sucrose-lactisole-serotonin Adding lactisole to sucrose lowered the plasma serotonin change at 30 minutes relative to sucrose alone. Model/species: 27 healthy men in randomized single-blinded crossover Tissue: Subsequent food intake and peripheral hormone measurements Exposure: 300 mL of 10% w/v sucrose with or without 60 ppm lactisole; parallel glucose conditions Route: Oral test drink after overnight fast Duration: 120 minutes; breakfast at 2 hours Exposure scope: Sucrose and taste antagonist Limits: Acute experiment in men; peripheral serotonin is not brain serotonin. Receptor mediation and binding-affinity explanation were not directly established; no long-term weight outcome. Reference: Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. (2020). https://pubmed.ncbi.nlm.nih.gov/33066498/ DOI: 10.3390/nu12103133 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.