Component

Mouse STRA8

Mouse germ-cell regulator studied in meiotic initiation; distinguish from the Stra8 gene and human STRA8.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. MEIOSIN was identified as a germ-cell factor associating with STRA8.

    Mouse MEIOSIN → Mouse STRA8 source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Protein association and functional analysis
    exposure
    Association assays; detailed conditions unavailable in abstract.
    limitations
    No binding stoichiometry or direct purified-protein affinity is asserted.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    Two germ-cell regulators work together.
    primary_references
    [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    tissue_or_cell_type
    mouse germ cells

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 239–250

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Protein association and functional analysis · source_derived_draft · unverified_draft

    ### va-repro-meiosin-stra8-association MEIOSIN was identified as a germ-cell factor associating with STRA8. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Two germ-cell regulators work together. organism: Mus musculus tissue_or_cell_type: mouse germ cells experimental_model: Protein association and functional analysis limitations: No binding stoichiometry or direct purified-protein affinity is asserted. exposure: Association assays; detailed conditions unavailable in abstract. cross_nutrient: false [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Loss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells.

    Mouse Meiosin gene → Mouse meiotic gene activation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Knockout and transcriptional functional analysis
    exposure
    Meiosin loss-of-function comparison.
    limitations
    Abstract-level extraction; no unverified individual promoter target is assigned.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    The meiotic program needs the MEIOSIN regulator.
    primary_references
    [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    tissue_or_cell_type
    male and female germ cells
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 252–263

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Knockout and transcriptional functional analysis · source_derived_draft · unverified_draft

    ### va-repro-meiosin-transcription Loss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: The meiotic program needs the MEIOSIN regulator. organism: Mus musculus tissue_or_cell_type: male and female germ cells experimental_model: Knockout and transcriptional functional analysis limitations: Abstract-level extraction; no unverified individual promoter target is assigned. exposure: Meiosin loss-of-function comparison. cross_nutrient: false [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    Complete structured claim and evidence

  2. All-trans RA induced Stra8 RNA in cultured fetal mouse testes.

    All-trans-retinoic acid → Mouse Stra8 expression source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Embryonic gonad culture
    exposure
    E12.5 testes; 0.7 micromolar RA for 2 days.
    limitations
    RNA induction alone did not establish completed meiosis.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    RA can turn on Stra8 in fetal testicular germ cells.
    primary_references
    [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    tissue_or_cell_type
    fetal testis

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 161–172

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Embryonic gonad culture · source_derived_draft · unverified_draft

    ### va-repro-ra-mouse-stra8 All-trans RA induced Stra8 RNA in cultured fetal mouse testes. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: RA can turn on Stra8 in fetal testicular germ cells. organism: Mus musculus tissue_or_cell_type: fetal testis experimental_model: Embryonic gonad culture limitations: RNA induction alone did not establish completed meiosis. exposure: E12.5 testes; 0.7 micromolar RA for 2 days. cross_nutrient: false [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    Complete structured claim and evidence

  3. Fetal ovarian germ cells lacking all RARs expressed meiotic markers and reached zygotene, challenging an obligatory RAR trigger.

    Retinoic acid receptor family → Mouse fetal ovarian meiotic progression source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Timed receptor deletion with excision reporter
    exposure
    Tamoxifen induction at E9.5; meiosis assessed at E15.5.
    limitations
    Does not test dietary vitamin A deprivation or every possible RAR-independent action.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    The tested fetal ovarian program progressed without the RA receptors.
    primary_references
    [vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139
    tissue_or_cell_type
    fetal ovary
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 304–315

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Timed receptor deletion with excision reporter · source_derived_draft · unverified_draft

    ### va-repro-rar-null-ovarian-meiosis Fetal ovarian germ cells lacking all RARs expressed meiotic markers and reached zygotene, challenging an obligatory RAR trigger. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested fetal ovarian program progressed without the RA receptors. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Timed receptor deletion with excision reporter limitations: Does not test dietary vitamin A deprivation or every possible RAR-independent action. exposure: Tamoxifen induction at E9.5; meiosis assessed at E15.5. cross_nutrient: false [vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139
    Complete structured claim and evidence

  4. Stra8-null female embryonic germ cells failed premeiotic DNA replication despite normal earlier mitotic development.

    Mouse Stra8 gene → Mouse ovarian premeiotic DNA replication source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Targeted Stra8 disruption
    exposure
    Stra8-null versus control embryos; no nutrient withdrawal.
    limitations
    Female replication result; male knockout phenotypes cannot be inferred from it.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    STRA8 acts before the ovarian cell copies its DNA for meiosis.
    primary_references
    [baltus2006] In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. (2006). https://pubmed.ncbi.nlm.nih.gov/17115059/ DOI: 10.1038/ng1919
    tissue_or_cell_type
    fetal ovary
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 213–224

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted Stra8 disruption · source_derived_draft · unverified_draft

    ### va-repro-stra8-premeiotic-replication Stra8-null female embryonic germ cells failed premeiotic DNA replication despite normal earlier mitotic development. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: STRA8 acts before the ovarian cell copies its DNA for meiosis. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Targeted Stra8 disruption limitations: Female replication result; male knockout phenotypes cannot be inferred from it. exposure: Stra8-null versus control embryos; no nutrient withdrawal. cross_nutrient: false [baltus2006] In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. (2006). https://pubmed.ncbi.nlm.nih.gov/17115059/ DOI: 10.1038/ng1919
    Complete structured claim and evidence

  5. Maternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression.

    L-Ascorbic acid → Mouse fetal ovarian meiotic progression source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    experimental_model
    Nutrient withdrawal with histology and meiotic staging
    exposure
    Withdrawal before mating through E13.5; same-genotype supplemented controls; staging at E14.5.
    limitations
    The individual SYCP3-positive protein fraction was not significantly reduced; this is not an A-C supplementation trial.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    A second nutrient shortage affected the germ-cell program also studied in vitamin A biology.
    primary_references
    [ditroia2019] Maternal vitamin C regulates reprogramming of DNA methylation and germline development. (2019). https://pubmed.ncbi.nlm.nih.gov/31485074/ DOI: 10.1038/s41586-019-1536-1
    tissue_or_cell_type
    female fetal ovary
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 382–393

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nutrient withdrawal with histology and meiotic staging · source_derived_draft · unverified_draft

    ### va-repro-vitamin-c-meiotic-delay Maternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression. Condition category: nutrient_deficiency nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second nutrient shortage affected the germ-cell program also studied in vitamin A biology. organism: Mus musculus tissue_or_cell_type: female fetal ovary experimental_model: Nutrient withdrawal with histology and meiotic staging limitations: The individual SYCP3-positive protein fraction was not significantly reduced; this is not an A-C supplementation trial. exposure: Withdrawal before mating through E13.5; same-genotype supplemented controls; staging at E14.5. cross_nutrient: true [ditroia2019] Maternal vitamin C regulates reprogramming of DNA methylation and germline development. (2019). https://pubmed.ncbi.nlm.nih.gov/31485074/ DOI: 10.1038/s41586-019-1536-1
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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