Component

Mouse Stra8 expression

Abundance of Stra8 RNA in the specified mouse germ-cell context.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. CYP26 inhibition with R115866 induced Stra8 in cultured fetal mouse testes.

    R115866 / talarozole → Mouse Stra8 expression source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Embryonic gonad culture
    exposure
    E12.5 testes; 0.7 micromolar R115866 for 2 days.
    limitations
    The inhibitor experiment did not establish bona fide meiotic prophase.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    Local retinoid breakdown restrains the Stra8 response.
    primary_references
    [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    tissue_or_cell_type
    fetal testis

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 174–185

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Embryonic gonad culture · source_derived_draft · unverified_draft

    ### va-repro-cyp26-inhibitor-stra8 CYP26 inhibition with R115866 induced Stra8 in cultured fetal mouse testes. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Local retinoid breakdown restrains the Stra8 response. organism: Mus musculus tissue_or_cell_type: fetal testis experimental_model: Embryonic gonad culture limitations: The inhibitor experiment did not establish bona fide meiotic prophase. exposure: E12.5 testes; 0.7 micromolar R115866 for 2 days. cross_nutrient: false [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    Complete structured claim and evidence

  2. All-trans RA induced Stra8 RNA in cultured fetal mouse testes.

    All-trans-retinoic acid → Mouse Stra8 expression source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Embryonic gonad culture
    exposure
    E12.5 testes; 0.7 micromolar RA for 2 days.
    limitations
    RNA induction alone did not establish completed meiosis.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    RA can turn on Stra8 in fetal testicular germ cells.
    primary_references
    [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    tissue_or_cell_type
    fetal testis

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 161–172

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Embryonic gonad culture · source_derived_draft · unverified_draft

    ### va-repro-ra-mouse-stra8 All-trans RA induced Stra8 RNA in cultured fetal mouse testes. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: RA can turn on Stra8 in fetal testicular germ cells. organism: Mus musculus tissue_or_cell_type: fetal testis experimental_model: Embryonic gonad culture limitations: RNA induction alone did not establish completed meiosis. exposure: E12.5 testes; 0.7 micromolar RA for 2 days. cross_nutrient: false [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    Complete structured claim and evidence

  3. The 2006 study inferred that RAR signaling is required for fetal ovarian Stra8 induction after BMS-204493 suppressed its expression.

    Retinoic acid receptor family → Mouse Stra8 expression source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Pharmacologic model inference
    exposure
    E11.5 ovaries; 5 micromolar BMS-204493 for 2 days.
    limitations
    Disputed necessity inference; receptor repression differs from receptor deletion.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    An early drug experiment supported a requirement later challenged by genetics.
    primary_references
    [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    tissue_or_cell_type
    fetal ovary

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 187–198

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pharmacologic model inference · source_derived_draft · unverified_draft

    ### va-repro-rar-necessity-model The 2006 study inferred that RAR signaling is required for fetal ovarian Stra8 induction after BMS-204493 suppressed its expression. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: An early drug experiment supported a requirement later challenged by genetics. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Pharmacologic model inference limitations: Disputed necessity inference; receptor repression differs from receptor deletion. exposure: E11.5 ovaries; 5 micromolar BMS-204493 for 2 days. cross_nutrient: false [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
    Complete structured claim and evidence

  4. Targeted mutation of Stra8 RA-response elements reduced its expression in fetal mouse ovaries.

    Mouse Stra8 gene → Mouse Stra8 expression source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    CRISPR/Cas9 cis-regulatory mutation
    exposure
    RARE1 and RARE3 mutated singly or together; endogenous Stra8 expression assessed in vivo.
    limitations
    Reduced optimal expression does not establish complete loss of expression or prove an obligatory RA trigger for all ovarian meiosis.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    Later genetic promoter tests confirmed a contribution from RA-responsive DNA elements.
    primary_references
    [feng2021] Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. (2021). https://pubmed.ncbi.nlm.nih.gov/33574039/ DOI: 10.1242/dev.194977
    tissue_or_cell_type
    fetal ovarian germ cells
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 395–406

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CRISPR/Cas9 cis-regulatory mutation · source_derived_draft · unverified_draft

    ### va-repro-stra8-rare-mutations Targeted mutation of Stra8 RA-response elements reduced its expression in fetal mouse ovaries. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Later genetic promoter tests confirmed a contribution from RA-responsive DNA elements. organism: Mus musculus tissue_or_cell_type: fetal ovarian germ cells experimental_model: CRISPR/Cas9 cis-regulatory mutation limitations: Reduced optimal expression does not establish complete loss of expression or prove an obligatory RA trigger for all ovarian meiosis. exposure: RARE1 and RARE3 mutated singly or together; endogenous Stra8 expression assessed in vivo. cross_nutrient: false [feng2021] Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. (2021). https://pubmed.ncbi.nlm.nih.gov/33574039/ DOI: 10.1242/dev.194977
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards