Component
Mouse Stra8 gene
Gene disrupted in the embryonic premeiotic replication experiment.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Stra8-null female embryonic germ cells failed premeiotic DNA replication despite normal earlier mitotic development.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Targeted Stra8 disruption
- exposure
- Stra8-null versus control embryos; no nutrient withdrawal.
- limitations
- Female replication result; male knockout phenotypes cannot be inferred from it.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- STRA8 acts before the ovarian cell copies its DNA for meiosis.
- primary_references
- [baltus2006] In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. (2006). https://pubmed.ncbi.nlm.nih.gov/17115059/ DOI: 10.1038/ng1919
- tissue_or_cell_type
- fetal ovary
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 213–224
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted Stra8 disruption · source_derived_draft · unverified_draft
### va-repro-stra8-premeiotic-replication Stra8-null female embryonic germ cells failed premeiotic DNA replication despite normal earlier mitotic development. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: STRA8 acts before the ovarian cell copies its DNA for meiosis. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Targeted Stra8 disruption limitations: Female replication result; male knockout phenotypes cannot be inferred from it. exposure: Stra8-null versus control embryos; no nutrient withdrawal. cross_nutrient: false [baltus2006] In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. (2006). https://pubmed.ncbi.nlm.nih.gov/17115059/ DOI: 10.1038/ng1919
Complete structured claim and evidenceTargeted mutation of Stra8 RA-response elements reduced its expression in fetal mouse ovaries.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- CRISPR/Cas9 cis-regulatory mutation
- exposure
- RARE1 and RARE3 mutated singly or together; endogenous Stra8 expression assessed in vivo.
- limitations
- Reduced optimal expression does not establish complete loss of expression or prove an obligatory RA trigger for all ovarian meiosis.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Later genetic promoter tests confirmed a contribution from RA-responsive DNA elements.
- primary_references
- [feng2021] Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. (2021). https://pubmed.ncbi.nlm.nih.gov/33574039/ DOI: 10.1242/dev.194977
- tissue_or_cell_type
- fetal ovarian germ cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 395–406
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CRISPR/Cas9 cis-regulatory mutation · source_derived_draft · unverified_draft
### va-repro-stra8-rare-mutations Targeted mutation of Stra8 RA-response elements reduced its expression in fetal mouse ovaries. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Later genetic promoter tests confirmed a contribution from RA-responsive DNA elements. organism: Mus musculus tissue_or_cell_type: fetal ovarian germ cells experimental_model: CRISPR/Cas9 cis-regulatory mutation limitations: Reduced optimal expression does not establish complete loss of expression or prove an obligatory RA trigger for all ovarian meiosis. exposure: RARE1 and RARE3 mutated singly or together; endogenous Stra8 expression assessed in vivo. cross_nutrient: false [feng2021] Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. (2021). https://pubmed.ncbi.nlm.nih.gov/33574039/ DOI: 10.1242/dev.194977
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.