{"id":"ad845454-50b1-55c3-845c-2d6d92a57679","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-vitamin-c-meiotic-delay","predicate":"maternal_depletion_delays","statement":"Maternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"dffa018d-554c-5995-9636-4cc6aa6dc4fb","mechanism_event_label":"A second nutrient shortage affected the germ-cell program also studied in vitamin A biology.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"bceb97ad-9929-5d6c-8c95-c54f11954938","slug":"mouse-fetal-ovarian-meiotic-progression","display_name":"Mouse fetal ovarian meiotic progression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dffa018d-554c-5995-9636-4cc6aa6dc4fb","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-vitamin-c-meiotic-delay-event","event_type":"biochemical_relationship","label":"A second nutrient shortage affected the germ-cell program also studied in vitamin A biology.","description":"Maternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cdfcd658-889e-5002-8167-15af0f8130ae","slug":"mouse-stra8","display_name":"Mouse STRA8","entity_type_key":"protein"},"role":"shared_meiotic_regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"be39243b-1d20-58c9-9f76-1480560334ac","slug":"tet1-mouse","display_name":"Mouse Tet1","entity_type_key":"protein"},"role":"related_epigenetic_machinery","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bceb97ad-9929-5d6c-8c95-c54f11954938","slug":"mouse-fetal-ovarian-meiotic-progression","display_name":"Mouse fetal ovarian meiotic progression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nutrient withdrawal with histology and meiotic staging","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Withdrawal before mating through E13.5; same-genotype supplemented controls; staging at E14.5.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The individual SYCP3-positive protein fraction was not significantly reduced; this is not an A-C supplementation trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A second nutrient shortage affected the germ-cell program also studied in vitamin A biology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ditroia2019] Maternal vitamin C regulates reprogramming of DNA methylation and germline development. (2019). https://pubmed.ncbi.nlm.nih.gov/31485074/ DOI: 10.1038/s41586-019-1536-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"female fetal ovary","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"ab981867-70b4-5e34-99a5-5f439d6985e8","evidence_kind":"source_excerpt","locator":"Lines 382-393","start_line":382,"end_line":393,"excerpt":"### va-repro-vitamin-c-meiotic-delay\nMaternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A second nutrient shortage affected the germ-cell program also studied in vitamin A biology.\norganism: Mus musculus\ntissue_or_cell_type: female fetal ovary\nexperimental_model: Nutrient withdrawal with histology and meiotic staging\nlimitations: The individual SYCP3-positive protein fraction was not significantly reduced; this is not an A-C supplementation trial.\nexposure: Withdrawal before mating through E13.5; same-genotype supplemented controls; staging at E14.5.\ncross_nutrient: true\n[ditroia2019] Maternal vitamin C regulates reprogramming of DNA methylation and germline development. 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