{"id":"1c260f73-258d-50d7-9df9-d2b9fb1591cf","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-meiosin-transcription","predicate":"loss_impairs","statement":"Loss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"09e52e56-a546-590d-9787-486c3353b4e8","mechanism_event_label":"The meiotic program needs the MEIOSIN regulator.","subject":{"id":"e40d93f0-7022-5c23-9b03-1e53780f7773","slug":"mouse-meiosin-gene","display_name":"Mouse Meiosin gene","entity_type_key":"gene"},"object":{"id":"9e044683-0e88-584f-999e-41643979d8bf","slug":"mouse-meiotic-gene-activation","display_name":"Mouse meiotic gene activation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"09e52e56-a546-590d-9787-486c3353b4e8","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-meiosin-transcription-event","event_type":"biochemical_relationship","label":"The meiotic program needs the MEIOSIN regulator.","description":"Loss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a8dcb98c-d19a-5710-8ab8-f640b988b97a","slug":"mouse-meiosin","display_name":"Mouse MEIOSIN","entity_type_key":"protein"},"role":"missing_factor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cdfcd658-889e-5002-8167-15af0f8130ae","slug":"mouse-stra8","display_name":"Mouse STRA8","entity_type_key":"protein"},"role":"cooperating_factor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e40d93f0-7022-5c23-9b03-1e53780f7773","slug":"mouse-meiosin-gene","display_name":"Mouse Meiosin gene","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9e044683-0e88-584f-999e-41643979d8bf","slug":"mouse-meiotic-gene-activation","display_name":"Mouse meiotic gene activation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Knockout and transcriptional functional analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Meiosin loss-of-function comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract-level extraction; no unverified individual promoter target is assigned.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The meiotic program needs the MEIOSIN regulator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"male and female germ cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"917a74d1-b944-5bd6-94c0-a8212606d192","evidence_kind":"source_excerpt","locator":"Lines 252-263","start_line":252,"end_line":263,"excerpt":"### va-repro-meiosin-transcription\nLoss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The meiotic program needs the MEIOSIN regulator.\norganism: Mus musculus\ntissue_or_cell_type: male and female germ cells\nexperimental_model: Knockout and transcriptional functional analysis\nlimitations: Abstract-level extraction; no unverified individual promoter target is assigned.\nexposure: Meiosin loss-of-function comparison.\ncross_nutrient: false\n[ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. 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