{"id":"fb5ee2e9-b2bf-5d16-8007-3c29a12e822c","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-meiosin-stra8-association","predicate":"associates_with","statement":"MEIOSIN was identified as a germ-cell factor associating with STRA8.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"239faffa-8a46-5142-a780-2ba88b9af9b0","mechanism_event_label":"Two germ-cell regulators work together.","subject":{"id":"a8dcb98c-d19a-5710-8ab8-f640b988b97a","slug":"mouse-meiosin","display_name":"Mouse MEIOSIN","entity_type_key":"protein"},"object":{"id":"cdfcd658-889e-5002-8167-15af0f8130ae","slug":"mouse-stra8","display_name":"Mouse STRA8","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"239faffa-8a46-5142-a780-2ba88b9af9b0","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-meiosin-stra8-association-event","event_type":"biochemical_relationship","label":"Two germ-cell regulators work together.","description":"MEIOSIN was identified as a germ-cell factor associating with STRA8.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a8dcb98c-d19a-5710-8ab8-f640b988b97a","slug":"mouse-meiosin","display_name":"Mouse MEIOSIN","entity_type_key":"protein"},"role":"transcription_factor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cdfcd658-889e-5002-8167-15af0f8130ae","slug":"mouse-stra8","display_name":"Mouse STRA8","entity_type_key":"protein"},"role":"associated_factor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein association and functional analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Association assays; detailed conditions unavailable in abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No binding stoichiometry or direct purified-protein affinity is asserted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Two germ-cell regulators work together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"mouse germ cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a8fb2ab5-7f8f-5e5b-911e-7bb049841875","evidence_kind":"source_excerpt","locator":"Lines 239-250","start_line":239,"end_line":250,"excerpt":"### va-repro-meiosin-stra8-association\nMEIOSIN was identified as a germ-cell factor associating with STRA8.\nCondition category: normal\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Two germ-cell regulators work together.\norganism: Mus musculus\ntissue_or_cell_type: mouse germ cells\nexperimental_model: Protein association and functional analysis\nlimitations: No binding stoichiometry or direct purified-protein affinity is asserted.\nexposure: Association assays; detailed conditions unavailable in abstract.\ncross_nutrient: false\n[ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010","model_system":"Protein association and functional analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"83131a07-353f-5301-9ce6-50754c194952","stable_key":"import-3c852f36-7951-5fd9-9013-d771a8d16d8a","title":"Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"559cb4dc3f59519ecb0bc455dbcc73346fbf8e0c51e133f455781f51e4ed07ab","revision_id":"225fe4da-2d21-5c19-a92c-80a5f3cac8cb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}