Component

Mouse MEIOSIN

Mouse meiosis initiator transcription factor that associates with STRA8.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. MEIOSIN was identified as a germ-cell factor associating with STRA8.

    Mouse MEIOSIN → Mouse STRA8 source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Protein association and functional analysis
    exposure
    Association assays; detailed conditions unavailable in abstract.
    limitations
    No binding stoichiometry or direct purified-protein affinity is asserted.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    Two germ-cell regulators work together.
    primary_references
    [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    tissue_or_cell_type
    mouse germ cells

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 239–250

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Protein association and functional analysis · source_derived_draft · unverified_draft

    ### va-repro-meiosin-stra8-association MEIOSIN was identified as a germ-cell factor associating with STRA8. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Two germ-cell regulators work together. organism: Mus musculus tissue_or_cell_type: mouse germ cells experimental_model: Protein association and functional analysis limitations: No binding stoichiometry or direct purified-protein affinity is asserted. exposure: Association assays; detailed conditions unavailable in abstract. cross_nutrient: false [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Loss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells.

    Mouse Meiosin gene → Mouse meiotic gene activation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Knockout and transcriptional functional analysis
    exposure
    Meiosin loss-of-function comparison.
    limitations
    Abstract-level extraction; no unverified individual promoter target is assigned.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    The meiotic program needs the MEIOSIN regulator.
    primary_references
    [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    tissue_or_cell_type
    male and female germ cells
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 252–263

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Knockout and transcriptional functional analysis · source_derived_draft · unverified_draft

    ### va-repro-meiosin-transcription Loss of MEIOSIN impaired meiotic gene activation and the transition into meiosis in mouse germ cells. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: The meiotic program needs the MEIOSIN regulator. organism: Mus musculus tissue_or_cell_type: male and female germ cells experimental_model: Knockout and transcriptional functional analysis limitations: Abstract-level extraction; no unverified individual promoter target is assigned. exposure: Meiosin loss-of-function comparison. cross_nutrient: false [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    Complete structured claim and evidence

  2. MEIOSIN expression responded to RA in the reported mouse germ-cell experiments.

    All-trans-retinoic acid → Mouse MEIOSIN expression source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Mouse germ-cell expression analysis
    exposure
    RA-responsive expression; exact regimen unavailable in primary abstract.
    limitations
    Does not establish universal responsiveness at every spermatogonial stage.
    nutrient_topic
    Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    The vitamin A signal also induces a partner of STRA8.
    primary_references
    [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    tissue_or_cell_type
    developing germ cells

    Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 226–237

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse germ-cell expression analysis · source_derived_draft · unverified_draft

    ### va-repro-ra-meiosin-expression MEIOSIN expression responded to RA in the reported mouse germ-cell experiments. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: The vitamin A signal also induces a partner of STRA8. organism: Mus musculus tissue_or_cell_type: developing germ cells experimental_model: Mouse germ-cell expression analysis limitations: Does not establish universal responsiveness at every spermatogonial stage. exposure: RA-responsive expression; exact regimen unavailable in primary abstract. cross_nutrient: false [ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards