{"id":"22f22ae7-cd56-55e1-baeb-9f8f64fc1061","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-ra-meiosin-expression","predicate":"induces_expression","statement":"MEIOSIN expression responded to RA in the reported mouse germ-cell experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8b6a9a17-67f6-59e0-a8bf-9469395f7b74","mechanism_event_label":"The vitamin A signal also induces a partner of STRA8.","subject":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"object":{"id":"caf18de3-f672-59e6-afee-17eb2133a348","slug":"mouse-meiosin-expression","display_name":"Mouse MEIOSIN expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8b6a9a17-67f6-59e0-a8bf-9469395f7b74","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-ra-meiosin-expression-event","event_type":"biochemical_relationship","label":"The vitamin A signal also induces a partner of STRA8.","description":"MEIOSIN expression responded to RA in the reported mouse germ-cell experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a8dcb98c-d19a-5710-8ab8-f640b988b97a","slug":"mouse-meiosin","display_name":"Mouse MEIOSIN","entity_type_key":"protein"},"role":"induced_regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"caf18de3-f672-59e6-afee-17eb2133a348","slug":"mouse-meiosin-expression","display_name":"Mouse MEIOSIN expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse germ-cell expression analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"RA-responsive expression; exact regimen unavailable in primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish universal responsiveness at every spermatogonial stage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The vitamin A signal also induces a partner of STRA8.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. (2020). https://pubmed.ncbi.nlm.nih.gov/32032549/ DOI: 10.1016/j.devcel.2020.01.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"developing germ cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c900801a-2459-5f4b-b7fd-e84c46f8b466","evidence_kind":"source_excerpt","locator":"Lines 226-237","start_line":226,"end_line":237,"excerpt":"### va-repro-ra-meiosin-expression\nMEIOSIN expression responded to RA in the reported mouse germ-cell experiments.\nCondition category: normal\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The vitamin A signal also induces a partner of STRA8.\norganism: Mus musculus\ntissue_or_cell_type: developing germ cells\nexperimental_model: Mouse germ-cell expression analysis\nlimitations: Does not establish universal responsiveness at every spermatogonial stage.\nexposure: RA-responsive expression; exact regimen unavailable in primary abstract.\ncross_nutrient: false\n[ishiguro2020] MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. 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