Component
Mouse fetal ovarian meiotic progression
Progression of fetal ovarian germ cells through meiotic prophase; precise stage remains claim-specific.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Conditional deletion of Aldh1a1, Aldh1a2 and Aldh1a3 did not prevent fetal ovarian meiotic progression despite strongly reduced RA.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Three conditional deletion strategies
- exposure
- Somatic or ubiquitous Aldh1a1-3 ablation; ovarian analyses around E13.5-E16.5.
- limitations
- Minor Stra8 delay occurred; analytically zero RA from every source was not demonstrated.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Removing the main RA-synthesis enzymes did not stop fetal ovarian meiosis.
- primary_references
- [chassot2020] Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. (2020). https://pubmed.ncbi.nlm.nih.gov/32494737/ DOI: 10.1126/sciadv.aaz1261
- tissue_or_cell_type
- fetal ovary
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 291–302
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three conditional deletion strategies · source_derived_draft · unverified_draft
### va-repro-aldh-loss-ovarian-meiosis Conditional deletion of Aldh1a1, Aldh1a2 and Aldh1a3 did not prevent fetal ovarian meiotic progression despite strongly reduced RA. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing the main RA-synthesis enzymes did not stop fetal ovarian meiosis. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Three conditional deletion strategies limitations: Minor Stra8 delay occurred; analytically zero RA from every source was not demonstrated. exposure: Somatic or ubiquitous Aldh1a1-3 ablation; ovarian analyses around E13.5-E16.5. cross_nutrient: false [chassot2020] Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. (2020). https://pubmed.ncbi.nlm.nih.gov/32494737/ DOI: 10.1126/sciadv.aaz1261
Complete structured claim and evidenceFetal ovarian germ cells lacking all RARs expressed meiotic markers and reached zygotene, challenging an obligatory RAR trigger.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Timed receptor deletion with excision reporter
- exposure
- Tamoxifen induction at E9.5; meiosis assessed at E15.5.
- limitations
- Does not test dietary vitamin A deprivation or every possible RAR-independent action.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- The tested fetal ovarian program progressed without the RA receptors.
- primary_references
- [vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139
- tissue_or_cell_type
- fetal ovary
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 304–315
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Timed receptor deletion with excision reporter · source_derived_draft · unverified_draft
### va-repro-rar-null-ovarian-meiosis Fetal ovarian germ cells lacking all RARs expressed meiotic markers and reached zygotene, challenging an obligatory RAR trigger. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested fetal ovarian program progressed without the RA receptors. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Timed receptor deletion with excision reporter limitations: Does not test dietary vitamin A deprivation or every possible RAR-independent action. exposure: Tamoxifen induction at E9.5; meiosis assessed at E15.5. cross_nutrient: false [vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139
Complete structured claim and evidenceMaternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- true
- experimental_model
- Nutrient withdrawal with histology and meiotic staging
- exposure
- Withdrawal before mating through E13.5; same-genotype supplemented controls; staging at E14.5.
- limitations
- The individual SYCP3-positive protein fraction was not significantly reduced; this is not an A-C supplementation trial.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- A second nutrient shortage affected the germ-cell program also studied in vitamin A biology.
- primary_references
- [ditroia2019] Maternal vitamin C regulates reprogramming of DNA methylation and germline development. (2019). https://pubmed.ncbi.nlm.nih.gov/31485074/ DOI: 10.1038/s41586-019-1536-1
- tissue_or_cell_type
- female fetal ovary
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 382–393
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nutrient withdrawal with histology and meiotic staging · source_derived_draft · unverified_draft
### va-repro-vitamin-c-meiotic-delay Maternal vitamin C deficiency delayed female fetal meiotic progression, with reduced STRA8 expression. Condition category: nutrient_deficiency nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second nutrient shortage affected the germ-cell program also studied in vitamin A biology. organism: Mus musculus tissue_or_cell_type: female fetal ovary experimental_model: Nutrient withdrawal with histology and meiotic staging limitations: The individual SYCP3-positive protein fraction was not significantly reduced; this is not an A-C supplementation trial. exposure: Withdrawal before mating through E13.5; same-genotype supplemented controls; staging at E14.5. cross_nutrient: true [ditroia2019] Maternal vitamin C regulates reprogramming of DNA methylation and germline development. (2019). https://pubmed.ncbi.nlm.nih.gov/31485074/ DOI: 10.1038/s41586-019-1536-1
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.