Component

Intestinal manganese absorption

Intestinal manganese absorption. Experimental scope belongs to each linked claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Adding phytate, phosphate or ascorbic acid to the formula test meals did not significantly alter manganese absorption in adults.

    Intestinal manganese absorption → Phytic acid / phytate source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Inorganic phosphate (Pi; protonation depends on pH) (tested_addition); L-Ascorbate (tested_addition); Manganese (measured_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912}
    experimental_model
    Paired radiotracer test-meal study in adults
    exposure
    Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.
    limitations
    These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The tested additions had no detectable effect in this formula matrix.
    primary_references
    [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    tissue_or_cell_type
    Intestinal absorption

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1062–1074

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired radiotracer test-meal study in adults · source_derived_draft · unverified_draft

    ### mn-clin-meal-formula-additions Adding phytate, phosphate or ascorbic acid to the formula test meals did not significantly alter manganese absorption in adults. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested additions had no detectable effect in this formula matrix. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption experimental_model: Paired radiotracer test-meal study in adults limitations: These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows. exposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions. cross_nutrient: Inorganic phosphate (Pi; protonation depends on pH) (tested_addition); L-Ascorbate (tested_addition); Manganese (measured_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912} [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    Complete structured claim and evidence

  2. Men absorbed less manganese tracer than women but retained the absorbed tracer for longer.

    Intestinal manganese absorption → Whole-body manganese retention source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Plasma ferritin concentration (associated_biomarker); Iron (possible_context)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009}
    experimental_model
    Whole-body manganese tracer study in 20 men and 20 women
    exposure
    Adequate-manganese diet and oral tracer meal; counting continued for 70 days.
    limitations
    Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Lower absorption did not mean faster loss afterward.
    primary_references
    [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
    tissue_or_cell_type
    Intestinal absorption and whole-body retention

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1076–1088

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body manganese tracer study in 20 men and 20 women · source_derived_draft · unverified_draft

    ### mn-clin-sex-absorption-retention Men absorbed less manganese tracer than women but retained the absorbed tracer for longer. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lower absorption did not mean faster loss afterward. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption and whole-body retention experimental_model: Whole-body manganese tracer study in 20 men and 20 women limitations: Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here. exposure: Adequate-manganese diet and oral tracer meal; counting continued for 70 days. cross_nutrient: Plasma ferritin concentration (associated_biomarker); Iron (possible_context) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009} [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
    Complete structured claim and evidence

What acts on it

  1. Manganese absorption was greatest in the low-ferritin group on the low-manganese diet and lowest in the high-ferritin group.

    Serum ferritin concentration → Intestinal manganese absorption source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    Iron (interacting_nutrient); Manganese (absorbed_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/finley1999.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "start_char": 0, "end_char": 1731, "text_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "text_characters": 1731}
    experimental_model
    Crossover isotope study in 26 healthy young women
    exposure
    Eleven women with serum ferritin >50 micrograms/L and 15 with <15 micrograms/L; diets at 0.7 or 9.5 mg Mn/day for 60 days each.
    limitations
    Ferritin defines the comparison groups, not cellular manganese deficiency. Retention and absorption are separate measurements; the study does not identify a specific transporter as their cause.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The amount of manganese absorbed depended partly on iron stores.
    primary_references
    [mn-clin-finley1999] Manganese absorption and retention by young women is associated with serum ferritin concentration. (1999). https://pubmed.ncbi.nlm.nih.gov/10393136/ DOI: 10.1093/ajcn/70.1.37
    tissue_or_cell_type
    Gut, whole-body tracer retention and blood
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 978–990

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Crossover isotope study in 26 healthy young women · source_derived_draft · unverified_draft

    ### mn-clin-iron-stores-absorption Manganese absorption was greatest in the low-ferritin group on the low-manganese diet and lowest in the high-ferritin group. Condition category: biomarker_context nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The amount of manganese absorbed depended partly on iron stores. organism: Homo sapiens tissue_or_cell_type: Gut, whole-body tracer retention and blood experimental_model: Crossover isotope study in 26 healthy young women limitations: Ferritin defines the comparison groups, not cellular manganese deficiency. Retention and absorption are separate measurements; the study does not identify a specific transporter as their cause. exposure: Eleven women with serum ferritin >50 micrograms/L and 15 with <15 micrograms/L; diets at 0.7 or 9.5 mg Mn/day for 60 days each. cross_nutrient: Iron (interacting_nutrient); Manganese (absorbed_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/finley1999.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "start_char": 0, "end_char": 1731, "text_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "text_characters": 1731} [mn-clin-finley1999] Manganese absorption and retention by young women is associated with serum ferritin concentration. (1999). https://pubmed.ncbi.nlm.nih.gov/10393136/ DOI: 10.1093/ajcn/70.1.37
    Complete structured claim and evidence

  2. Adding calcium to the human-milk test meal reduced manganese absorption in adults.

    Calcium → Intestinal manganese absorption source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Manganese (absorbed_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912}
    experimental_model
    Paired radiotracer test-meal study in adults
    exposure
    Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.
    limitations
    These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Calcium changed manganese uptake in this particular meal.
    primary_references
    [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    tissue_or_cell_type
    Intestinal absorption

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1020–1032

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired radiotracer test-meal study in adults · source_derived_draft · unverified_draft

    ### mn-clin-meal-calcium Adding calcium to the human-milk test meal reduced manganese absorption in adults. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcium changed manganese uptake in this particular meal. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption experimental_model: Paired radiotracer test-meal study in adults limitations: These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows. exposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions. cross_nutrient: Manganese (absorbed_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912} [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    Complete structured claim and evidence

  3. Iron added to the wheat-bread test meal did not significantly change manganese absorption.

    Iron → Intestinal manganese absorption source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Manganese (measured_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912}
    experimental_model
    Paired radiotracer test-meal study in adults
    exposure
    Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.
    limitations
    These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    An iron interaction was not detected in every meal.
    primary_references
    [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    tissue_or_cell_type
    Intestinal absorption

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1034–1046

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired radiotracer test-meal study in adults · source_derived_draft · unverified_draft

    ### mn-clin-meal-iron Iron added to the wheat-bread test meal did not significantly change manganese absorption. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: An iron interaction was not detected in every meal. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption experimental_model: Paired radiotracer test-meal study in adults limitations: These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows. exposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions. cross_nutrient: Manganese (measured_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912} [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    Complete structured claim and evidence

  4. Magnesium added to the wheat-bread test meal did not significantly change manganese absorption.

    Magnesium → Intestinal manganese absorption source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Manganese (measured_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912}
    experimental_model
    Paired radiotracer test-meal study in adults
    exposure
    Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.
    limitations
    These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Magnesium did not inhibit manganese uptake in this bread experiment.
    primary_references
    [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    tissue_or_cell_type
    Intestinal absorption

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1048–1060

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired radiotracer test-meal study in adults · source_derived_draft · unverified_draft

    ### mn-clin-meal-magnesium Magnesium added to the wheat-bread test meal did not significantly change manganese absorption. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Magnesium did not inhibit manganese uptake in this bread experiment. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption experimental_model: Paired radiotracer test-meal study in adults limitations: These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows. exposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions. cross_nutrient: Manganese (measured_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davidsson1991.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "start_char": 0, "end_char": 912, "text_sha256": "7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a", "text_characters": 912} [mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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