{"id":"85652ae9-0a37-5e92-b11d-f32024a67cb1","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-meal-iron","predicate":"did_not_significantly_change","statement":"Iron added to the wheat-bread test meal did not significantly change manganese absorption.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"5468ff4a-1913-572e-a20a-442ed9abdc32","mechanism_event_label":"An iron interaction was not detected in every meal.","subject":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"object":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5468ff4a-1913-572e-a20a-442ed9abdc32","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-meal-iron-event","event_type":"observed_intervention","label":"An iron interaction was not detected in every meal.","description":"Iron added to the wheat-bread test meal did not significantly change manganese absorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"measured_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Manganese (measured_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/davidsson1991.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"start_char\": 0, \"end_char\": 912, \"text_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"text_characters\": 912}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Paired radiotracer test-meal study in adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An iron interaction was not detected in every meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"625ea8fb-9a9d-5edf-a211-0fa3c02cb568","evidence_kind":"source_excerpt","locator":"Lines 1034-1046","start_line":1034,"end_line":1046,"excerpt":"### mn-clin-meal-iron\nIron added to the wheat-bread test meal did not significantly change manganese absorption.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An iron interaction was not detected in every meal.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal absorption\nexperimental_model: Paired radiotracer test-meal study in adults\nlimitations: These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.\nexposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.\ncross_nutrient: Manganese (measured_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/davidsson1991.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"start_char\": 0, \"end_char\": 912, \"text_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"text_characters\": 912}\n[mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. 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