{"id":"fe0458aa-aaf0-5c78-9c72-288f152ba88a","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-meal-formula-additions","predicate":"showed_no_significant_response_to","statement":"Adding phytate, phosphate or ascorbic acid to the formula test meals did not significantly alter manganese absorption in adults.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"2110fc79-df53-5564-9511-e7cac07764d7","mechanism_event_label":"The tested additions had no detectable effect in this formula matrix.","subject":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"object":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2110fc79-df53-5564-9511-e7cac07764d7","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-meal-formula-additions-event","event_type":"observed_intervention","label":"The tested additions had no detectable effect in this formula matrix.","description":"Adding phytate, phosphate or ascorbic acid to the formula test meals did not significantly alter manganese absorption in adults.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; protonation depends on pH)","entity_type_key":"ion"},"role":"tested_addition","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"tested_addition","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"measured_nutrient","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Inorganic phosphate (Pi; protonation depends on pH) (tested_addition); L-Ascorbate (tested_addition); Manganese (measured_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/davidsson1991.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"start_char\": 0, \"end_char\": 912, \"text_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"text_characters\": 912}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Paired radiotracer test-meal study in adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The tested additions had no detectable effect in this formula matrix.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. (1991). https://pubmed.ncbi.nlm.nih.gov/1957822/ DOI: 10.1093/ajcn/54.6.1065","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"983e2510-eeb2-5659-842b-cd919e99831b","evidence_kind":"source_excerpt","locator":"Lines 1062-1074","start_line":1062,"end_line":1074,"excerpt":"### mn-clin-meal-formula-additions\nAdding phytate, phosphate or ascorbic acid to the formula test meals did not significantly alter manganese absorption in adults.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The tested additions had no detectable effect in this formula matrix.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal absorption\nexperimental_model: Paired radiotracer test-meal study in adults\nlimitations: These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.\nexposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.\ncross_nutrient: Inorganic phosphate (Pi; protonation depends on pH) (tested_addition); L-Ascorbate (tested_addition); Manganese (measured_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/davidsson1991.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"start_char\": 0, \"end_char\": 912, \"text_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"text_characters\": 912}\n[mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. 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