{"id":"9245708d-a6d0-51e2-8167-ab8fdcaeb907","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-meal-calcium","predicate":"reduced","statement":"Adding calcium to the human-milk test meal reduced manganese absorption in adults.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"88c72ed6-13a7-549e-8d88-cf0bd49f5453","mechanism_event_label":"Calcium changed manganese uptake in this particular meal.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"88c72ed6-13a7-549e-8d88-cf0bd49f5453","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-meal-calcium-event","event_type":"observed_intervention","label":"Calcium changed manganese uptake in this particular meal.","description":"Adding calcium to the human-milk test meal reduced manganese absorption in adults.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"absorbed_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Manganese (absorbed_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/davidsson1991.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"start_char\": 0, \"end_char\": 912, \"text_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"text_characters\": 912}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Paired radiotracer test-meal study in adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These were adult experiments even when milk or infant formula was the matrix. Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcium changed manganese uptake in this particular meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. 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Added amounts were not independently verified from the indexed abstract; no universal interaction or spacing rule follows.\nexposure: Human milk, infant formula and wheat bread used as adult test meals; individual mineral and dietary-component additions.\ncross_nutrient: Manganese (absorbed_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/davidsson1991.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"start_char\": 0, \"end_char\": 912, \"text_sha256\": \"7570e2285532eac2292b252a3813f1be97b46d68529a4d4150a88b4f9038676a\", \"text_characters\": 912}\n[mn-clin-davidsson1991] The effect of individual dietary components on manganese absorption in humans. 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