{"id":"358c8536-0b17-5533-ba7e-43c6734e8bb1","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-sex-absorption-retention","predicate":"differed_with","statement":"Men absorbed less manganese tracer than women but retained the absorbed tracer for longer.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"227310d9-3d71-5817-b93e-fe28eecb2c83","mechanism_event_label":"Lower absorption did not mean faster loss afterward.","subject":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"object":{"id":"090b0624-64b7-5766-b41b-78230567ff1c","slug":"whole-body-manganese-retention","display_name":"Whole-body manganese retention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"227310d9-3d71-5817-b93e-fe28eecb2c83","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-sex-absorption-retention-event","event_type":"observed_intervention","label":"Lower absorption did not mean faster loss afterward.","description":"Men absorbed less manganese tracer than women but retained the absorbed tracer for longer.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"95c37a9b-d089-5cfc-bd50-5c5877403a60","slug":"plasma-ferritin-concentration","display_name":"Plasma ferritin concentration","entity_type_key":"cellular_process"},"role":"associated_biomarker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"possible_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6190ea2f-a7a9-5eca-8438-cf13e428ddff","slug":"intestinal-manganese-absorption","display_name":"Intestinal manganese absorption","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"090b0624-64b7-5766-b41b-78230567ff1c","slug":"whole-body-manganese-retention","display_name":"Whole-body manganese retention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Plasma ferritin concentration (associated_biomarker); Iron (possible_context)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/finley1994.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0\", \"start_char\": 0, \"end_char\": 1009, \"text_sha256\": \"f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0\", \"text_characters\": 1009}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Whole-body manganese tracer study in 20 men and 20 women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Adequate-manganese diet and oral tracer meal; counting continued for 70 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lower absorption did not mean faster loss afterward.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal absorption and whole-body retention","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8a41ab67-6f35-5545-977f-28ea7f741ec8","evidence_kind":"source_excerpt","locator":"Lines 1076-1088","start_line":1076,"end_line":1088,"excerpt":"### mn-clin-sex-absorption-retention\nMen absorbed less manganese tracer than women but retained the absorbed tracer for longer.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Lower absorption did not mean faster loss afterward.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal absorption and whole-body retention\nexperimental_model: Whole-body manganese tracer study in 20 men and 20 women\nlimitations: Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here.\nexposure: Adequate-manganese diet and oral tracer meal; counting continued for 70 days.\ncross_nutrient: Plasma ferritin concentration (associated_biomarker); Iron (possible_context)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/finley1994.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0\", \"start_char\": 0, \"end_char\": 1009, \"text_sha256\": \"f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0\", \"text_characters\": 1009}\n[mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. 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