Component

Whole-body manganese retention

Whole-body manganese retention. Experimental scope belongs to each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Men absorbed less manganese tracer than women but retained the absorbed tracer for longer.

    Intestinal manganese absorption → Whole-body manganese retention source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Plasma ferritin concentration (associated_biomarker); Iron (possible_context)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009}
    experimental_model
    Whole-body manganese tracer study in 20 men and 20 women
    exposure
    Adequate-manganese diet and oral tracer meal; counting continued for 70 days.
    limitations
    Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Lower absorption did not mean faster loss afterward.
    primary_references
    [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
    tissue_or_cell_type
    Intestinal absorption and whole-body retention

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1076–1088

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body manganese tracer study in 20 men and 20 women · source_derived_draft · unverified_draft

    ### mn-clin-sex-absorption-retention Men absorbed less manganese tracer than women but retained the absorbed tracer for longer. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lower absorption did not mean faster loss afterward. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption and whole-body retention experimental_model: Whole-body manganese tracer study in 20 men and 20 women limitations: Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here. exposure: Adequate-manganese diet and oral tracer meal; counting continued for 70 days. cross_nutrient: Plasma ferritin concentration (associated_biomarker); Iron (possible_context) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009} [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
    Complete structured claim and evidence

  2. Fitting days 10–20 gave higher absorption and shorter half-life estimates than fitting days 19–70 of the same retention curves.

    Manganese tracer biological half-life → Whole-body manganese retention source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Manganese handling and the measured downstream function.
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009}
    experimental_model
    Whole-body manganese tracer study in 20 men and 20 women
    exposure
    Adequate-manganese diet and oral tracer meal; counting continued for 70 days.
    limitations
    Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The observation window changed the calculated manganese estimates.
    primary_references
    [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
    tissue_or_cell_type
    Intestinal absorption and whole-body retention

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1090–1102

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body manganese tracer study in 20 men and 20 women · source_derived_draft · unverified_draft

    ### mn-clin-tracer-window Fitting days 10–20 gave higher absorption and shorter half-life estimates than fitting days 19–70 of the same retention curves. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The observation window changed the calculated manganese estimates. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption and whole-body retention experimental_model: Whole-body manganese tracer study in 20 men and 20 women limitations: Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here. exposure: Adequate-manganese diet and oral tracer meal; counting continued for 70 days. cross_nutrient: Manganese handling and the measured downstream function. evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009} [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards