Component
Manganese tracer biological half-life
Manganese tracer biological half-life. Experimental scope belongs to each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Fitting days 10–20 gave higher absorption and shorter half-life estimates than fitting days 19–70 of the same retention curves.
Experimental context and source evidence
- cross_nutrient
- Manganese handling and the measured downstream function.
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009}
- experimental_model
- Whole-body manganese tracer study in 20 men and 20 women
- exposure
- Adequate-manganese diet and oral tracer meal; counting continued for 70 days.
- limitations
- Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- The observation window changed the calculated manganese estimates.
- primary_references
- [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
- tissue_or_cell_type
- Intestinal absorption and whole-body retention
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1090–1102
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body manganese tracer study in 20 men and 20 women · source_derived_draft · unverified_draft
### mn-clin-tracer-window Fitting days 10–20 gave higher absorption and shorter half-life estimates than fitting days 19–70 of the same retention curves. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The observation window changed the calculated manganese estimates. organism: Homo sapiens tissue_or_cell_type: Intestinal absorption and whole-body retention experimental_model: Whole-body manganese tracer study in 20 men and 20 women limitations: Sex-associated findings may reflect iron status and other differences. Reported tracer-activity units in the abstract were not independently verified and are not used here. exposure: Adequate-manganese diet and oral tracer meal; counting continued for 70 days. cross_nutrient: Manganese handling and the measured downstream function. evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/finley1994.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "start_char": 0, "end_char": 1009, "text_sha256": "f24059b0e56ddb384da59918af300da971697d38bdac6be5775a39d65f5209a0", "text_characters": 1009} [mn-clin-finley1994] Sex affects manganese absorption and retention by humans from a diet adequate in manganese. (1994). https://pubmed.ncbi.nlm.nih.gov/7985639/ DOI: 10.1093/ajcn/60.6.949
Complete structured claim and evidence
What acts on it
Tracer half-life was longest with high ferritin and low manganese intake, and shortest during the high-manganese diets.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- Iron (interacting_nutrient); Manganese (retained_nutrient)
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/finley1999.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "start_char": 0, "end_char": 1731, "text_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "text_characters": 1731}
- experimental_model
- Crossover isotope study in 26 healthy young women
- exposure
- Eleven women with serum ferritin >50 micrograms/L and 15 with <15 micrograms/L; diets at 0.7 or 9.5 mg Mn/day for 60 days each.
- limitations
- Ferritin defines the comparison groups, not cellular manganese deficiency. Retention and absorption are separate measurements; the study does not identify a specific transporter as their cause.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- Absorbing manganese and keeping it are separately regulated.
- primary_references
- [mn-clin-finley1999] Manganese absorption and retention by young women is associated with serum ferritin concentration. (1999). https://pubmed.ncbi.nlm.nih.gov/10393136/ DOI: 10.1093/ajcn/70.1.37
- tissue_or_cell_type
- Gut, whole-body tracer retention and blood
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 992–1004
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Crossover isotope study in 26 healthy young women · source_derived_draft · unverified_draft
### mn-clin-iron-stores-retention Tracer half-life was longest with high ferritin and low manganese intake, and shortest during the high-manganese diets. Condition category: biomarker_context nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Absorbing manganese and keeping it are separately regulated. organism: Homo sapiens tissue_or_cell_type: Gut, whole-body tracer retention and blood experimental_model: Crossover isotope study in 26 healthy young women limitations: Ferritin defines the comparison groups, not cellular manganese deficiency. Retention and absorption are separate measurements; the study does not identify a specific transporter as their cause. exposure: Eleven women with serum ferritin >50 micrograms/L and 15 with <15 micrograms/L; diets at 0.7 or 9.5 mg Mn/day for 60 days each. cross_nutrient: Iron (interacting_nutrient); Manganese (retained_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/finley1999.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "start_char": 0, "end_char": 1731, "text_sha256": "3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7", "text_characters": 1731} [mn-clin-finley1999] Manganese absorption and retention by young women is associated with serum ferritin concentration. (1999). https://pubmed.ncbi.nlm.nih.gov/10393136/ DOI: 10.1093/ajcn/70.1.37
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.