{"id":"1576452d-ac5a-52c1-91ec-f10a30223d9b","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-iron-stores-retention","predicate":"was_associated_with","statement":"Tracer half-life was longest with high ferritin and low manganese intake, and shortest during the high-manganese diets.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"32b4613c-178e-5a26-999e-d0ea3e163c95","mechanism_event_label":"Absorbing manganese and keeping it are separately regulated.","subject":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"object":{"id":"9a12f087-5a0e-5a47-adb3-9448d2400ff8","slug":"manganese-biological-half-life","display_name":"Manganese tracer biological half-life","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"32b4613c-178e-5a26-999e-d0ea3e163c95","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-iron-stores-retention-event","event_type":"observed_intervention","label":"Absorbing manganese and keeping it are separately regulated.","description":"Tracer half-life was longest with high ferritin and low manganese intake, and shortest during the high-manganese diets.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"interacting_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"retained_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9a12f087-5a0e-5a47-adb3-9448d2400ff8","slug":"manganese-biological-half-life","display_name":"Manganese tracer biological half-life","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Iron (interacting_nutrient); Manganese (retained_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/finley1999.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7\", \"start_char\": 0, \"end_char\": 1731, \"text_sha256\": \"3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7\", \"text_characters\": 1731}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Crossover isotope study in 26 healthy young women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Eleven women with serum ferritin >50 micrograms/L and 15 with <15 micrograms/L; diets at 0.7 or 9.5 mg Mn/day for 60 days each.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ferritin defines the comparison groups, not cellular manganese deficiency. Retention and absorption are separate measurements; the study does not identify a specific transporter as their cause.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Absorbing manganese and keeping it are separately regulated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-finley1999] Manganese absorption and retention by young women is associated with serum ferritin concentration. 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Retention and absorption are separate measurements; the study does not identify a specific transporter as their cause.\nexposure: Eleven women with serum ferritin >50 micrograms/L and 15 with <15 micrograms/L; diets at 0.7 or 9.5 mg Mn/day for 60 days each.\ncross_nutrient: Iron (interacting_nutrient); Manganese (retained_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/finley1999.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7\", \"start_char\": 0, \"end_char\": 1731, \"text_sha256\": \"3ec791f205459093fec1dfac522bbb6241aa1199894886be9c64d4c2eb2b97d7\", \"text_characters\": 1731}\n[mn-clin-finley1999] Manganese absorption and retention by young women is associated with serum ferritin concentration. 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