Component

Human organic anion transporter 3 / SLC22A8

Context-specific entity; species, compartment and exposure are stated on each claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Steviol trans-stimulated tracer efflux through human OAT3 expressed in Xenopus oocytes.

    Human organic anion transporter 3 / SLC22A8 → Steviol source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human cloned transporter in frog oocytes.
    limitations
    OAT3 and OATP transporters are different families and are not merged here.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    A second renal organic-anion transporter handles the same metabolite.
    primary_references
    Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
    transport_effect
    depends Inferred from trans-stimulation of a tracer's efflux, which shows movement without fixing its direction.
    transport_pool
    the cytosol across the basolateral membrane Inferred from trans-stimulation of a tracer's efflux, which shows movement without fixing its direction.

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 106–112

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human cloned transporter in frog oocytes. · source_derived_draft · unverified_draft

    ## stevia-oat3 A second renal organic-anion transporter handles the same metabolite. Steviol trans-stimulated tracer efflux through human OAT3 expressed in Xenopus oocytes. Model: Human cloned transporter in frog oocytes. Limitations: OAT3 and OATP transporters are different families and are not merged here. Evidence access: Primary abstract Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
    Complete structured claim and evidence

  2. OAT3 mediated predominant uptake of steviol glucuronide relative to the tested OATP1B1, OATP1B3 and OATP2B1 systems.

    Human organic anion transporter 3 / SLC22A8 → Steviol glucuronide source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    In vitro transporter-expression comparison.
    limitations
    This compares tested systems, not every renal transporter or complete epithelial excretion.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Conjugation changes the molecule without ending transporter dependence.
    primary_references
    Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
    transport_effect
    raises Recorded as predominant uptake of steviol glucuronide relative to the other tested systems.
    transport_pool
    the expressing cell Recorded as predominant uptake of steviol glucuronide relative to the other tested systems.

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 122–128

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · In vitro transporter-expression comparison. · source_derived_draft · unverified_draft

    ## stevia-svg-oat3 Conjugation changes the molecule without ending transporter dependence. OAT3 mediated predominant uptake of steviol glucuronide relative to the tested OATP1B1, OATP1B3 and OATP2B1 systems. Model: In vitro transporter-expression comparison. Limitations: This compares tested systems, not every renal transporter or complete epithelial excretion. Evidence access: Primary abstract Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
    Complete structured claim and evidence

What acts on it

  1. Stevioside did not inhibit human OAT3-mediated estrone-sulfate uptake or OAT1-mediated para-aminohippurate uptake, whereas steviol did.

    Stevioside → Human organic anion transporter 3 / SLC22A8 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human OAT expression in Xenopus oocytes.
    limitations
    A negative uptake-inhibition assay does not rule out all other transporters.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    The parent sweetener and its metabolite do not share every transport interaction.
    primary_references
    Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 114–120

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human OAT expression in Xenopus oocytes. · source_derived_draft · unverified_draft

    ## stevia-parent-oat-null The parent sweetener and its metabolite do not share every transport interaction. Stevioside did not inhibit human OAT3-mediated estrone-sulfate uptake or OAT1-mediated para-aminohippurate uptake, whereas steviol did. Model: Human OAT expression in Xenopus oocytes. Limitations: A negative uptake-inhibition assay does not rule out all other transporters. Evidence access: Primary abstract Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Diclofenac inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 8.0 micromolar.

    Diclofenac → Human OAT3-mediated steviol-glucuronide uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    In vitro uptake assay; distinct from the glucuronidation experiment.
    limitations
    Combining the two records does not quantify a net in vivo interaction.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    The same drug intersects two different clearance steps.
    primary_references
    Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 138–144

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · In vitro uptake assay; distinct from the glucuronidation experiment. · source_derived_draft · unverified_draft

    ## stevia-diclofenac-oat3 The same drug intersects two different clearance steps. Diclofenac inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 8.0 micromolar. Model: In vitro uptake assay; distinct from the glucuronidation experiment. Limitations: Combining the two records does not quantify a net in vivo interaction. Evidence access: Primary abstract Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
    Complete structured claim and evidence

  2. Quercetin inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 1.8 micromolar.

    Quercetin → Human OAT3-mediated steviol-glucuronide uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    In vitro transport inhibition assay.
    limitations
    Free tissue exposure and a human pharmacokinetic interaction were not established.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    A food-derived flavonoid intersects the metabolite clearance route.
    primary_references
    Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 130–136

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · In vitro transport inhibition assay. · source_derived_draft · unverified_draft

    ## stevia-quercetin-oat3 A food-derived flavonoid intersects the metabolite clearance route. Quercetin inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 1.8 micromolar. Model: In vitro transport inhibition assay. Limitations: Free tissue exposure and a human pharmacokinetic interaction were not established. Evidence access: Primary abstract Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards