{"id":"23abe1f3-752d-5389-99b9-ecb43ff17466","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-svg-oat3","predicate":"transports","statement":"OAT3 mediated predominant uptake of steviol glucuronide relative to the tested OATP1B1, OATP1B3 and OATP2B1 systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"483fd6ea-4ad6-5c8b-930c-be0a5ecd323c","mechanism_event_label":"Conjugation changes the molecule without ending transporter dependence.","subject":{"id":"4606352d-ad2e-580f-87eb-e0ccf0d02fd9","slug":"slc22a8","display_name":"Human organic anion transporter 3 / SLC22A8","entity_type_key":"protein"},"object":{"id":"f008b74d-164b-5663-a72e-04a48fe7a8fb","slug":"steviol-glucuronide","display_name":"Steviol glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"483fd6ea-4ad6-5c8b-930c-be0a5ecd323c","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-svg-oat3-event","event_type":"observed_relationship","label":"Conjugation changes the molecule without ending transporter dependence.","description":"OAT3 mediated predominant uptake of steviol glucuronide relative to the tested OATP1B1, OATP1B3 and OATP2B1 systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4606352d-ad2e-580f-87eb-e0ccf0d02fd9","slug":"slc22a8","display_name":"Human organic anion transporter 3 / SLC22A8","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f008b74d-164b-5663-a72e-04a48fe7a8fb","slug":"steviol-glucuronide","display_name":"Steviol glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In vitro transporter-expression comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This compares tested systems, not every renal transporter or complete epithelial excretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Conjugation changes the molecule without ending transporter dependence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Recorded as predominant uptake of steviol glucuronide relative to the other tested systems.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Recorded as predominant uptake of steviol glucuronide relative to the other tested systems.","entity":null}],"evidence":[{"id":"9d808c3b-267a-58ae-8a9b-db0ebbbb9134","evidence_kind":"source_excerpt","locator":"Lines 122-128","start_line":122,"end_line":128,"excerpt":"## stevia-svg-oat3\nConjugation changes the molecule without ending transporter dependence.\nOAT3 mediated predominant uptake of steviol glucuronide relative to the tested OATP1B1, OATP1B3 and OATP2B1 systems.\nModel: In vitro transporter-expression comparison.\nLimitations: This compares tested systems, not every renal transporter or complete epithelial excretion.\nEvidence access: Primary abstract\nTransmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011","model_system":"In vitro transporter-expression comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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