Component
Human OAT3-mediated steviol-glucuronide uptake
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Diclofenac inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 8.0 micromolar.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- In vitro uptake assay; distinct from the glucuronidation experiment.
- limitations
- Combining the two records does not quantify a net in vivo interaction.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- The same drug intersects two different clearance steps.
- primary_references
- Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 138–144
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · In vitro uptake assay; distinct from the glucuronidation experiment. · source_derived_draft · unverified_draft
## stevia-diclofenac-oat3 The same drug intersects two different clearance steps. Diclofenac inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 8.0 micromolar. Model: In vitro uptake assay; distinct from the glucuronidation experiment. Limitations: Combining the two records does not quantify a net in vivo interaction. Evidence access: Primary abstract Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
Complete structured claim and evidenceQuercetin inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 1.8 micromolar.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- In vitro transport inhibition assay.
- limitations
- Free tissue exposure and a human pharmacokinetic interaction were not established.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- A food-derived flavonoid intersects the metabolite clearance route.
- primary_references
- Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 130–136
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · In vitro transport inhibition assay. · source_derived_draft · unverified_draft
## stevia-quercetin-oat3 A food-derived flavonoid intersects the metabolite clearance route. Quercetin inhibited OAT3-mediated steviol-glucuronide uptake, with IC50 1.8 micromolar. Model: In vitro transport inhibition assay. Limitations: Free tissue exposure and a human pharmacokinetic interaction were not established. Evidence access: Primary abstract Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26525112/ · DOI 10.1016/j.fct.2015.10.011
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.