Component

Mouse ZIP14 (Slc39a14)

Mus musculus ZIP14 multimetal transporter protein.

11 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Mouse ZIP14 did not increase uptake of radiolabeled copper supplied as Cu(I) or Cu(II) in the tested oocyte conditions.

    Mouse ZIP14 (Slc39a14) → Cellular copper uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    Radiolabeled Cu(I) and Cu(II) uptake in Xenopus oocytes
    exposure
    Cu(I) and Cu(II) tested separately against controls.
    limitations
    A bounded negative result does not mean zinc and copper have no interaction through other proteins or intestinal mechanisms.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    This ZIP14 experiment found no copper transport despite detecting other metal substrates.
    primary_references
    [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 518–529

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiolabeled Cu(I) and Cu(II) uptake in Xenopus oocytes · source_derived_draft · unverified_draft

    ### zinc-trans-zip14-copper-negative Mouse ZIP14 did not increase uptake of radiolabeled copper supplied as Cu(I) or Cu(II) in the tested oocyte conditions. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: This ZIP14 experiment found no copper transport despite detecting other metal substrates. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: Radiolabeled Cu(I) and Cu(II) uptake in Xenopus oocytes limitations: A bounded negative result does not mean zinc and copper have no interaction through other proteins or intestinal mechanisms. exposure: Cu(I) and Cu(II) tested separately against controls. cross_nutrient: true [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

  2. Mouse ZIP14 directly mediated 54Mn(II) uptake in RNA-injected Xenopus oocytes.

    Mouse ZIP14 (Slc39a14) → Cellular manganese uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    RNA-injected Xenopus oocytes with radiolabeled metal uptake
    exposure
    54Mn transport compared with uninjected controls.
    limitations
    Transport capacity is not proof that manganese supplements improve zinc transport or vice versa.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    ZIP14 could carry manganese as well as zinc in this experiment.
    primary_references
    [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 492–503

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · RNA-injected Xenopus oocytes with radiolabeled metal uptake · source_derived_draft · unverified_draft

    ### zinc-trans-zip14-manganese-influx Mouse ZIP14 directly mediated 54Mn(II) uptake in RNA-injected Xenopus oocytes. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: ZIP14 could carry manganese as well as zinc in this experiment. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: RNA-injected Xenopus oocytes with radiolabeled metal uptake limitations: Transport capacity is not proof that manganese supplements improve zinc transport or vice versa. exposure: 54Mn transport compared with uninjected controls. cross_nutrient: true [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

  3. Mouse ZIP14 expression in Xenopus oocytes supported saturable zinc uptake with an apparent half-maximal zinc concentration near 2 micromolar.

    Mouse ZIP14 (Slc39a14) → Cellular zinc influx source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    RNA-injected Xenopus oocytes and 65Zn uptake
    exposure
    Zinc concentration-response curve under the study transport conditions.
    limitations
    The apparent affinity belongs to this assay, not a serum zinc cutoff; protein is the mouse ortholog.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    Mouse ZIP14 directly carried zinc in the oocyte assay.
    primary_references
    [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 479–490

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · RNA-injected Xenopus oocytes and 65Zn uptake · source_derived_draft · unverified_draft

    ### zinc-trans-zip14-zinc-influx Mouse ZIP14 expression in Xenopus oocytes supported saturable zinc uptake with an apparent half-maximal zinc concentration near 2 micromolar. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Mouse ZIP14 directly carried zinc in the oocyte assay. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: RNA-injected Xenopus oocytes and 65Zn uptake limitations: The apparent affinity belongs to this assay, not a serum zinc cutoff; protein is the mouse ortholog. exposure: Zinc concentration-response curve under the study transport conditions. cross_nutrient: false [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

  4. ZIP14-specific siRNA reduced apical manganese uptake in polarized mouse proximal-tubule cells.

    Mouse ZIP14 (Slc39a14) → Cellular manganese uptake source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture
    exposure
    ZIP14 siRNA versus controls during apical manganese exposure.
    limitations
    Cell culture supports an uptake contribution; it does not quantify in vivo urinary reabsorption or rank transporter contributions.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mus musculus
    plain_language
    ZIP14 helped kidney-derived cells take up manganese from their lumen-facing side.
    primary_references
    [mn-trans-22534978] Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. (2012). https://pubmed.ncbi.nlm.nih.gov/22534978/ DOI: 10.1039/c2mt20024d
    tissue_or_cell_type
    Proximal-tubule epithelial cells, apical membrane
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 331–342

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture · source_derived_draft · unverified_draft

    ### mn-trans-renal-zip14 ZIP14-specific siRNA reduced apical manganese uptake in polarized mouse proximal-tubule cells. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: ZIP14 helped kidney-derived cells take up manganese from their lumen-facing side. organism: Mus musculus tissue_or_cell_type: Proximal-tubule epithelial cells, apical membrane experimental_model: Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture limitations: Cell culture supports an uptake contribution; it does not quantify in vivo urinary reabsorption or rank transporter contributions. exposure: ZIP14 siRNA versus controls during apical manganese exposure. cross_nutrient: false [mn-trans-22534978] Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. (2012). https://pubmed.ncbi.nlm.nih.gov/22534978/ DOI: 10.1039/c2mt20024d
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Zinc inhibited mouse ZIP14-mediated Fe(II) uptake in Xenopus oocytes.

    Zinc(II) ion → Cellular iron uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    Mouse ZIP14 in Xenopus oocytes
    exposure
    Radiolabeled ferrous iron uptake with competing zinc.
    limitations
    Ferrous and ferric iron are distinct. This competition does not establish in vivo dietary interactions; transport properties vary by substrate.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    Zinc interfered with ferrous iron entry through ZIP14 in the transport assay.
    primary_references
    [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 505–516

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse ZIP14 in Xenopus oocytes · source_derived_draft · unverified_draft

    ### zinc-trans-zip14-zinc-inhibits-iron Zinc inhibited mouse ZIP14-mediated Fe(II) uptake in Xenopus oocytes. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Zinc interfered with ferrous iron entry through ZIP14 in the transport assay. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: Mouse ZIP14 in Xenopus oocytes limitations: Ferrous and ferric iron are distinct. This competition does not establish in vivo dietary interactions; transport properties vary by substrate. exposure: Radiolabeled ferrous iron uptake with competing zinc. cross_nutrient: true [zinc-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

  2. Liver-specific Zip14 knockout reduced liver manganese without producing manganese accumulation in other tissues under the reported normal conditions.

    Mouse liver-specific Slc39a14 knockout genotype → Extrahepatic manganese accumulation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Liver-specific Slc39a14 knockout mice
    exposure
    Liver-specific Slc39a14 knockout under normal study conditions.
    limitations
    A conditional negative result does not exclude a hepatic contribution when intestinal clearance is also impaired.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mus musculus
    plain_language
    Liver ZIP14 loss alone did not reproduce whole-body manganese overload.
    primary_references
    [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
    tissue_or_cell_type
    Liver and extrahepatic tissues
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 214–225

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Liver-specific Slc39a14 knockout mice · source_derived_draft · unverified_draft

    ### mn-trans-hepatic-zip14-loss-no-systemic-overload Liver-specific Zip14 knockout reduced liver manganese without producing manganese accumulation in other tissues under the reported normal conditions. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Liver ZIP14 loss alone did not reproduce whole-body manganese overload. organism: Mus musculus tissue_or_cell_type: Liver and extrahepatic tissues experimental_model: Liver-specific Slc39a14 knockout mice limitations: A conditional negative result does not exclude a hepatic contribution when intestinal clearance is also impaired. exposure: Liver-specific Slc39a14 knockout under normal study conditions. cross_nutrient: false [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
    Complete structured claim and evidence

  3. Intestine-specific Zip14 knockout increased liver and brain manganese in mice.

    Mouse intestine-specific Slc39a14 knockout genotype → Systemic manganese accumulation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Intestine-specific Slc39a14 knockout mice
    exposure
    Intestine-specific Slc39a14 knockout versus controls.
    limitations
    Liver and brain are specified outcomes; this statement does not imply every tissue or blood measure rose.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mus musculus
    plain_language
    Intestinal ZIP14 loss increased manganese retained in distant tissues.
    primary_references
    [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
    tissue_or_cell_type
    Intestine; manganese measured in liver and brain
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 227–238

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Intestine-specific Slc39a14 knockout mice · source_derived_draft · unverified_draft

    ### mn-trans-intestinal-zip14-loss-tissue-mn Intestine-specific Zip14 knockout increased liver and brain manganese in mice. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Intestinal ZIP14 loss increased manganese retained in distant tissues. organism: Mus musculus tissue_or_cell_type: Intestine; manganese measured in liver and brain experimental_model: Intestine-specific Slc39a14 knockout mice limitations: Liver and brain are specified outcomes; this statement does not imply every tissue or blood measure rose. exposure: Intestine-specific Slc39a14 knockout versus controls. cross_nutrient: false [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
    Complete structured claim and evidence

  4. Combined intestinal and hepatic Zip14 deletion increased systemic manganese burden more than intestinal deletion alone in mice.

    Mouse liver-and-intestine Slc39a14 double-knockout genotype → Systemic manganese accumulation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Single- and double-tissue Slc39a14 knockout mice; ICP-MS
    exposure
    Intestine-and-liver double knockout versus single-tissue knockout and floxed controls.
    limitations
    Supports organ cooperation, not a universal claim that liver-only deletion causes systemic overload.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mus musculus
    plain_language
    Liver ZIP14 became especially important when intestinal ZIP14 was also absent.
    primary_references
    [mn-trans-35742937] The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice. (2022). https://pubmed.ncbi.nlm.nih.gov/35742937/ DOI: 10.3390/ijms23126495
    tissue_or_cell_type
    Intestine, liver and systemic tissue manganese
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 357–368

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single- and double-tissue Slc39a14 knockout mice; ICP-MS · source_derived_draft · unverified_draft

    ### mn-trans-zip14-double-worsens-loading Combined intestinal and hepatic Zip14 deletion increased systemic manganese burden more than intestinal deletion alone in mice. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Liver ZIP14 became especially important when intestinal ZIP14 was also absent. organism: Mus musculus tissue_or_cell_type: Intestine, liver and systemic tissue manganese experimental_model: Single- and double-tissue Slc39a14 knockout mice; ICP-MS limitations: Supports organ cooperation, not a universal claim that liver-only deletion causes systemic overload. exposure: Intestine-and-liver double knockout versus single-tissue knockout and floxed controls. cross_nutrient: false [mn-trans-35742937] The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice. (2022). https://pubmed.ncbi.nlm.nih.gov/35742937/ DOI: 10.3390/ijms23126495
    Complete structured claim and evidence

  5. Fe(II) inhibited mouse ZIP14-mediated Mn(II) uptake in Xenopus oocytes under the tested competition conditions.

    Ferrous iron → Cellular manganese uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    Mouse ZIP14 in RNA-injected Xenopus laevis oocytes
    exposure
    2 micromolar radiolabeled Mn(II) with candidate inhibitor metal at 20 micromolar and 1 mM L-ascorbic acid; Figure 9B.
    limitations
    A tenfold molar competitor in a heterologous system is not a dietary competition threshold.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    Fe(II) competed with manganese entry through ZIP14 in this assay.
    primary_references
    [mn-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 305–316

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse ZIP14 in RNA-injected Xenopus laevis oocytes · source_derived_draft · unverified_draft

    ### mn-trans-zip14-fe-inhibits-mn Fe(II) inhibited mouse ZIP14-mediated Mn(II) uptake in Xenopus oocytes under the tested competition conditions. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Fe(II) competed with manganese entry through ZIP14 in this assay. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: Mouse ZIP14 in RNA-injected Xenopus laevis oocytes limitations: A tenfold molar competitor in a heterologous system is not a dietary competition threshold. exposure: 2 micromolar radiolabeled Mn(II) with candidate inhibitor metal at 20 micromolar and 1 mM L-ascorbic acid; Figure 9B. cross_nutrient: true [mn-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

  6. Mn(II) inhibited mouse ZIP14-mediated Fe(II) uptake in Xenopus oocytes.

    Mn2+ → Cellular iron uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    Mouse ZIP14 in RNA-injected Xenopus laevis oocytes
    exposure
    Radiolabeled Fe(II) uptake with added Mn(II).
    limitations
    Measured competition is assay-specific and does not establish dietary antagonism or ferric-iron transport.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    Manganese reduced ferrous iron entry through ZIP14 in the assay.
    primary_references
    [mn-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 292–303

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse ZIP14 in RNA-injected Xenopus laevis oocytes · source_derived_draft · unverified_draft

    ### mn-trans-zip14-mn-inhibits-fe Mn(II) inhibited mouse ZIP14-mediated Fe(II) uptake in Xenopus oocytes. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Manganese reduced ferrous iron entry through ZIP14 in the assay. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: Mouse ZIP14 in RNA-injected Xenopus laevis oocytes limitations: Measured competition is assay-specific and does not establish dietary antagonism or ferric-iron transport. exposure: Radiolabeled Fe(II) uptake with added Mn(II). cross_nutrient: true [mn-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

  7. Zn(II) inhibited mouse ZIP14-mediated Mn(II) uptake in Xenopus oocytes under the tested competition conditions.

    Zinc(II) ion → Cellular manganese uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    Mouse ZIP14 in RNA-injected Xenopus laevis oocytes
    exposure
    2 micromolar radiolabeled Mn(II) with candidate inhibitor metal at 20 micromolar and 1 mM L-ascorbic acid; Figure 9B.
    limitations
    A tenfold molar competitor in a heterologous system is not a dietary competition threshold.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mouse protein in Xenopus laevis oocytes
    plain_language
    Zn(II) competed with manganese entry through ZIP14 in this assay.
    primary_references
    [mn-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    tissue_or_cell_type
    Oocyte plasma membrane

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 318–329

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse ZIP14 in RNA-injected Xenopus laevis oocytes · source_derived_draft · unverified_draft

    ### mn-trans-zip14-zn-inhibits-mn Zn(II) inhibited mouse ZIP14-mediated Mn(II) uptake in Xenopus oocytes under the tested competition conditions. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Zn(II) competed with manganese entry through ZIP14 in this assay. organism: Mouse protein in Xenopus laevis oocytes tissue_or_cell_type: Oocyte plasma membrane experimental_model: Mouse ZIP14 in RNA-injected Xenopus laevis oocytes limitations: A tenfold molar competitor in a heterologous system is not a dietary competition threshold. exposure: 2 micromolar radiolabeled Mn(II) with candidate inhibitor metal at 20 micromolar and 1 mM L-ascorbic acid; Figure 9B. cross_nutrient: true [mn-trans-21653899] Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. (2011). https://pubmed.ncbi.nlm.nih.gov/21653899/ DOI: 10.1152/ajpcell.00479.2010
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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