Component
Mouse intestine-specific Slc39a14 knockout genotype
Mouse intestine-specific Slc39a14 knockout genotype
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Intestine-specific Zip14 knockout increased liver and brain manganese in mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Intestine-specific Slc39a14 knockout mice
- exposure
- Intestine-specific Slc39a14 knockout versus controls.
- limitations
- Liver and brain are specified outcomes; this statement does not imply every tissue or blood measure rose.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus
- plain_language
- Intestinal ZIP14 loss increased manganese retained in distant tissues.
- primary_references
- [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
- tissue_or_cell_type
- Intestine; manganese measured in liver and brain
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 227–238
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Intestine-specific Slc39a14 knockout mice · source_derived_draft · unverified_draft
### mn-trans-intestinal-zip14-loss-tissue-mn Intestine-specific Zip14 knockout increased liver and brain manganese in mice. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Intestinal ZIP14 loss increased manganese retained in distant tissues. organism: Mus musculus tissue_or_cell_type: Intestine; manganese measured in liver and brain experimental_model: Intestine-specific Slc39a14 knockout mice limitations: Liver and brain are specified outcomes; this statement does not imply every tissue or blood measure rose. exposure: Intestine-specific Slc39a14 knockout versus controls. cross_nutrient: false [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
Complete structured claim and evidence
Where it participates (unsigned role)
Combined intestinal and hepatic Zip14 deletion increased systemic manganese burden more than intestinal deletion alone in mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Single- and double-tissue Slc39a14 knockout mice; ICP-MS
- exposure
- Intestine-and-liver double knockout versus single-tissue knockout and floxed controls.
- limitations
- Supports organ cooperation, not a universal claim that liver-only deletion causes systemic overload.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus
- plain_language
- Liver ZIP14 became especially important when intestinal ZIP14 was also absent.
- primary_references
- [mn-trans-35742937] The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice. (2022). https://pubmed.ncbi.nlm.nih.gov/35742937/ DOI: 10.3390/ijms23126495
- tissue_or_cell_type
- Intestine, liver and systemic tissue manganese
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 357–368
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single- and double-tissue Slc39a14 knockout mice; ICP-MS · source_derived_draft · unverified_draft
### mn-trans-zip14-double-worsens-loading Combined intestinal and hepatic Zip14 deletion increased systemic manganese burden more than intestinal deletion alone in mice. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Liver ZIP14 became especially important when intestinal ZIP14 was also absent. organism: Mus musculus tissue_or_cell_type: Intestine, liver and systemic tissue manganese experimental_model: Single- and double-tissue Slc39a14 knockout mice; ICP-MS limitations: Supports organ cooperation, not a universal claim that liver-only deletion causes systemic overload. exposure: Intestine-and-liver double knockout versus single-tissue knockout and floxed controls. cross_nutrient: false [mn-trans-35742937] The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice. (2022). https://pubmed.ncbi.nlm.nih.gov/35742937/ DOI: 10.3390/ijms23126495
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.