{"id":"2a16a86a-0481-5175-939a-70720709652a","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-trans-intestinal-zip14-loss-tissue-mn","predicate":"increases","statement":"Intestine-specific Zip14 knockout increased liver and brain manganese in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"95feaa15-5daf-59dc-a16d-b8226bafcf38","mechanism_event_label":"Intestinal ZIP14 loss increased manganese retained in distant tissues.","subject":{"id":"6401516e-d2c5-56f0-9bf8-5616fe51f33b","slug":"mouse-intestinal-slc39a14-knockout","display_name":"Mouse intestine-specific Slc39a14 knockout genotype","entity_type_key":"gene"},"object":{"id":"000c1013-32a5-5c07-a0bb-4bf743acccf9","slug":"systemic-manganese-accumulation","display_name":"Systemic manganese accumulation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"95feaa15-5daf-59dc-a16d-b8226bafcf38","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-trans-intestinal-zip14-loss-tissue-mn-event","event_type":"biochemical_relationship","label":"Intestinal ZIP14 loss increased manganese retained in distant tissues.","description":"Intestine-specific Zip14 knockout increased liver and brain manganese in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a8082b11-c484-5792-bb81-48e8e699cbe4","slug":"manganese-ion","display_name":"Mn2+","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9e0e70ec-aa5b-584d-a6ea-28c400cb3100","slug":"mouse-slc39a14","display_name":"Mouse ZIP14 (Slc39a14)","entity_type_key":"protein"},"role":"affected_transporter","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6401516e-d2c5-56f0-9bf8-5616fe51f33b","slug":"mouse-intestinal-slc39a14-knockout","display_name":"Mouse intestine-specific Slc39a14 knockout genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"000c1013-32a5-5c07-a0bb-4bf743acccf9","slug":"systemic-manganese-accumulation","display_name":"Systemic manganese accumulation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Intestine-specific Slc39a14 knockout mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Intestine-specific Slc39a14 knockout versus controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Liver and brain are specified outcomes; this statement does not imply every tissue or blood measure rose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Intestinal ZIP14 loss increased manganese retained in distant tissues.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine; manganese measured in liver and brain","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"564eb2af-7ab2-5ce3-94a3-d8a50dd08aaf","evidence_kind":"source_excerpt","locator":"Lines 227-238","start_line":227,"end_line":238,"excerpt":"### mn-trans-intestinal-zip14-loss-tissue-mn\nIntestine-specific Zip14 knockout increased liver and brain manganese in mice.\nCondition category: machinery_impairment\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Intestinal ZIP14 loss increased manganese retained in distant tissues.\norganism: Mus musculus\ntissue_or_cell_type: Intestine; manganese measured in liver and brain\nexperimental_model: Intestine-specific Slc39a14 knockout mice\nlimitations: Liver and brain are specified outcomes; this statement does not imply every tissue or blood measure rose.\nexposure: Intestine-specific Slc39a14 knockout versus controls.\ncross_nutrient: false\n[mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. 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