Component
Extrahepatic manganese accumulation
Extrahepatic manganese accumulation
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Liver-specific Zip14 knockout reduced liver manganese without producing manganese accumulation in other tissues under the reported normal conditions.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Liver-specific Slc39a14 knockout mice
- exposure
- Liver-specific Slc39a14 knockout under normal study conditions.
- limitations
- A conditional negative result does not exclude a hepatic contribution when intestinal clearance is also impaired.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus
- plain_language
- Liver ZIP14 loss alone did not reproduce whole-body manganese overload.
- primary_references
- [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
- tissue_or_cell_type
- Liver and extrahepatic tissues
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 214–225
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Liver-specific Slc39a14 knockout mice · source_derived_draft · unverified_draft
### mn-trans-hepatic-zip14-loss-no-systemic-overload Liver-specific Zip14 knockout reduced liver manganese without producing manganese accumulation in other tissues under the reported normal conditions. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Liver ZIP14 loss alone did not reproduce whole-body manganese overload. organism: Mus musculus tissue_or_cell_type: Liver and extrahepatic tissues experimental_model: Liver-specific Slc39a14 knockout mice limitations: A conditional negative result does not exclude a hepatic contribution when intestinal clearance is also impaired. exposure: Liver-specific Slc39a14 knockout under normal study conditions. cross_nutrient: false [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.