Component

Intestinal magnesium absorption

Net transfer of magnesium from intestinal lumen toward the organism.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. High-dose supplemental zinc reduced measured Mg absorption in the pooled metabolic-balance groups.

    Zinc sulfate → Intestinal magnesium absorption source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Zinc -> magnesium availability; calcium intake recorded as context.
    experimental_model
    Adult men; three dietary calcium strata.
    exposure
    142 mg Zn/day as sulfate; calcium 230, 500 or 800 mg/day. Only the 500-mg stratum individually significant; pooled groups significant.
    limitations
    142 mg zinc/day is a high experimental exposure; ordinary food zinc effects and a shared transporter were not established.
    nutrient_topic
    Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
    organism
    Homo sapiens
    plain_language
    Large zinc exposure can interfere with magnesium uptake.
    primary_references
    [mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438
    tissue_or_cell_type
    Human intestinal absorption and metabolic balance

    Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1577–1588

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Adult men; three dietary calcium strata. · source_derived_draft · unverified_draft

    ### mg-high-zinc-lowers-absorption High-dose supplemental zinc reduced measured Mg absorption in the pooled metabolic-balance groups. Condition category: normal nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Large zinc exposure can interfere with magnesium uptake. organism: Homo sapiens tissue_or_cell_type: Human intestinal absorption and metabolic balance experimental_model: Adult men; three dietary calcium strata. limitations: 142 mg zinc/day is a high experimental exposure; ordinary food zinc effects and a shared transporter were not established. cross_nutrient: Zinc -> magnesium availability; calcium intake recorded as context. exposure: 142 mg Zn/day as sulfate; calcium 230, 500 or 800 mg/day. Only the 500-mg stratum individually significant; pooled groups significant. [mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438
    Complete structured claim and evidence

  2. Adding phytate to matched-Mg bread meals reduced fractional apparent Mg absorption in a dose-dependent pattern.

    Phytic acid / phytate → Intestinal magnesium absorption source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Dietary phytate -> magnesium uptake; mineral content and fractional absorption are distinct.
    experimental_model
    Two human crossover stable-isotope studies, 8-9 adults each.
    exposure
    1.49 mmol phytate: 32.5% to 13.0%; 0.75 mmol: 32.2% to 24.0%; 3.6 mmol Mg per meal.
    limitations
    Absorption is measured; mineral complexation was not isolated. Does not show that whole grains are net Mg-poor.
    nutrient_topic
    Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
    organism
    Homo sapiens
    plain_language
    A food component can reduce how much magnesium reaches the body from a meal.
    primary_references
    [mg-bohn2004] Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans (2004). https://pubmed.ncbi.nlm.nih.gov/14985216/ DOI: 10.1093/ajcn/79.3.418
    tissue_or_cell_type
    Human intestinal absorption estimated by fecal isotope recovery

    Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1602–1613

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two human crossover stable-isotope studies, 8-9 adults each. · source_derived_draft · unverified_draft

    ### mg-phytate-lowers-absorption Adding phytate to matched-Mg bread meals reduced fractional apparent Mg absorption in a dose-dependent pattern. Condition category: normal nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A food component can reduce how much magnesium reaches the body from a meal. organism: Homo sapiens tissue_or_cell_type: Human intestinal absorption estimated by fecal isotope recovery experimental_model: Two human crossover stable-isotope studies, 8-9 adults each. limitations: Absorption is measured; mineral complexation was not isolated. Does not show that whole grains are net Mg-poor. cross_nutrient: Dietary phytate -> magnesium uptake; mineral content and fractional absorption are distinct. exposure: 1.49 mmol phytate: 32.5% to 13.0%; 0.75 mmol: 32.2% to 24.0%; 3.6 mmol Mg per meal. [mg-bohn2004] Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans (2004). https://pubmed.ncbi.nlm.nih.gov/14985216/ DOI: 10.1093/ajcn/79.3.418
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Intestine-restricted Trpm6 deletion reduced serum and bone magnesium in the tested adult mice.

    Intestine-specific Trpm6-null mouse genotype → Serum magnesium concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence-system
    Villin1-Cre conditional deletion; six-month-old male mice
    experimental_model
    Villin1-Cre conditional deletion; six-month-old male mice
    limitations
    Colon expression was detected; the outcome does not quantify the contribution of each human intestinal segment.
    nutrient_topic
    Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
    organism
    Mouse
    plain_language
    Removing intestinal TRPM6 impaired systemic magnesium supply despite intact kidneys.
    primary_references
    [chubanov-2016-trpm6] Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival (2016). https://elifesciences.org/articles/20914 DOI: 10.7554/eLife.20914
    tissue
    Intestinal epithelium; serum and bone
    tissue_or_cell_type
    Intestinal epithelium; serum and bone
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 923–934

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Villin1-Cre conditional deletion; six-month-old male mice · source_derived_draft · unverified_draft

    ### intestinal-trpm6-loss-low-magnesium Intestine-restricted Trpm6 deletion reduced serum and bone magnesium in the tested adult mice. Condition category: machinery_impairment nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing intestinal TRPM6 impaired systemic magnesium supply despite intact kidneys. organism: Mouse tissue_or_cell_type: Intestinal epithelium; serum and bone experimental_model: Villin1-Cre conditional deletion; six-month-old male mice limitations: Colon expression was detected; the outcome does not quantify the contribution of each human intestinal segment. evidence-system: Villin1-Cre conditional deletion; six-month-old male mice tissue: Intestinal epithelium; serum and bone [chubanov-2016-trpm6] Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival (2016). https://elifesciences.org/articles/20914 DOI: 10.7554/eLife.20914
    Complete structured claim and evidence

  2. Higher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls.

    Calcium → Whole-body magnesium balance source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Calcium -> magnesium balance: a bounded null interaction.
    experimental_model
    Randomized crossover; Mg isotope kinetics.
    exposure
    Calcium 800 versus 1800 mg/day; Mg intakes about 305 versus 286 mg/day.
    limitations
    Very small and population-specific; a null result is not equivalence for all intakes or ages.
    nutrient_topic
    Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
    organism
    Homo sapiens
    plain_language
    Calcium and magnesium do not always compete enough to change measured balance.
    primary_references
    [mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710
    tissue_or_cell_type
    Human whole-body Mg isotope kinetics

    Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1615–1626

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover; Mg isotope kinetics. · source_derived_draft · unverified_draft

    ### mg-high-calcium-no-kinetic-difference Higher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls. Condition category: normal nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcium and magnesium do not always compete enough to change measured balance. organism: Homo sapiens tissue_or_cell_type: Human whole-body Mg isotope kinetics experimental_model: Randomized crossover; Mg isotope kinetics. limitations: Very small and population-specific; a null result is not equivalence for all intakes or ages. cross_nutrient: Calcium -> magnesium balance: a bounded null interaction. exposure: Calcium 800 versus 1800 mg/day; Mg intakes about 305 versus 286 mg/day. [mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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