{"id":"0df902e9-e089-5dca-ba55-700d9e386761","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-phytate-lowers-absorption","predicate":"reduces","statement":"Adding phytate to matched-Mg bread meals reduced fractional apparent Mg absorption in a dose-dependent pattern.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"03493b17-408d-562b-8751-ea72c8e0f1f6","mechanism_event_label":"A food component can reduce how much magnesium reaches the body from a meal.","subject":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"object":{"id":"1423c5f4-b9c1-52ed-9a82-19e5aeece6cb","slug":"intestinal-magnesium-absorption","display_name":"Intestinal magnesium absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"03493b17-408d-562b-8751-ea72c8e0f1f6","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-phytate-lowers-absorption-event","event_type":"observed_intervention","label":"A food component can reduce how much magnesium reaches the body from a meal.","description":"Adding phytate to matched-Mg bread meals reduced fractional apparent Mg absorption in a dose-dependent pattern.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"affected_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1423c5f4-b9c1-52ed-9a82-19e5aeece6cb","slug":"intestinal-magnesium-absorption","display_name":"Intestinal magnesium absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Dietary phytate -> magnesium uptake; mineral content and fractional absorption are distinct.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two human crossover stable-isotope studies, 8-9 adults each.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1.49 mmol phytate: 32.5% to 13.0%; 0.75 mmol: 32.2% to 24.0%; 3.6 mmol Mg per meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Absorption is measured; mineral complexation was not isolated. Does not show that whole grains are net Mg-poor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A food component can reduce how much magnesium reaches the body from a meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-bohn2004] Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans (2004). https://pubmed.ncbi.nlm.nih.gov/14985216/ DOI: 10.1093/ajcn/79.3.418","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human intestinal absorption estimated by fecal isotope recovery","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"82b6c845-0584-502e-b390-d056f6e51b91","evidence_kind":"source_excerpt","locator":"Lines 1602-1613","start_line":1602,"end_line":1613,"excerpt":"### mg-phytate-lowers-absorption\nAdding phytate to matched-Mg bread meals reduced fractional apparent Mg absorption in a dose-dependent pattern.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A food component can reduce how much magnesium reaches the body from a meal.\norganism: Homo sapiens\ntissue_or_cell_type: Human intestinal absorption estimated by fecal isotope recovery\nexperimental_model: Two human crossover stable-isotope studies, 8-9 adults each.\nlimitations: Absorption is measured; mineral complexation was not isolated. Does not show that whole grains are net Mg-poor.\ncross_nutrient: Dietary phytate -> magnesium uptake; mineral content and fractional absorption are distinct.\nexposure: 1.49 mmol phytate: 32.5% to 13.0%; 0.75 mmol: 32.2% to 24.0%; 3.6 mmol Mg per meal.\n[mg-bohn2004] Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans (2004). https://pubmed.ncbi.nlm.nih.gov/14985216/ DOI: 10.1093/ajcn/79.3.418","model_system":"Two human crossover stable-isotope studies, 8-9 adults each.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-bohn2004] Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans (2004). https://pubmed.ncbi.nlm.nih.gov/14985216/ DOI: 10.1093/ajcn/79.3.418","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}