{"id":"3df180a4-fef3-519a-93d1-105b5e6e0c52","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-high-calcium-no-kinetic-difference","predicate":"did_not_significantly_change","statement":"Higher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b010570c-88cd-529a-aeff-e5381b0ecb86","mechanism_event_label":"Calcium and magnesium do not always compete enough to change measured balance.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"2531a929-cde5-5ffa-aa2d-ffa9f2bee029","slug":"magnesium-balance","display_name":"Whole-body magnesium balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b010570c-88cd-529a-aeff-e5381b0ecb86","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-high-calcium-no-kinetic-difference-event","event_type":"observed_intervention","label":"Calcium and magnesium do not always compete enough to change measured balance.","description":"Higher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"tracked_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1423c5f4-b9c1-52ed-9a82-19e5aeece6cb","slug":"intestinal-magnesium-absorption","display_name":"Intestinal magnesium absorption","entity_type_key":"cellular_process"},"role":"measured_process","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2531a929-cde5-5ffa-aa2d-ffa9f2bee029","slug":"magnesium-balance","display_name":"Whole-body magnesium balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Calcium -> magnesium balance: a bounded null interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover; Mg isotope kinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Calcium 800 versus 1800 mg/day; Mg intakes about 305 versus 286 mg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very small and population-specific; a null result is not equivalence for all intakes or ages.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcium and magnesium do not always compete enough to change measured balance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human whole-body Mg isotope kinetics","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f8fb7297-aba9-562e-a068-2a802e0480e8","evidence_kind":"source_excerpt","locator":"Lines 1615-1626","start_line":1615,"end_line":1626,"excerpt":"### mg-high-calcium-no-kinetic-difference\nHigher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcium and magnesium do not always compete enough to change measured balance.\norganism: Homo sapiens\ntissue_or_cell_type: Human whole-body Mg isotope kinetics\nexperimental_model: Randomized crossover; Mg isotope kinetics.\nlimitations: Very small and population-specific; a null result is not equivalence for all intakes or ages.\ncross_nutrient: Calcium -> magnesium balance: a bounded null interaction.\nexposure: Calcium 800 versus 1800 mg/day; Mg intakes about 305 versus 286 mg/day.\n[mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710","model_system":"Randomized crossover; Mg isotope kinetics.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}