{"id":"ae34efc1-f2d0-5e62-85a8-47734bb48b6f","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-high-zinc-lowers-absorption","predicate":"high_intake_reduces","statement":"High-dose supplemental zinc reduced measured Mg absorption in the pooled metabolic-balance groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"0c44af2c-e4b8-5686-8a7f-fd456c9ee08a","mechanism_event_label":"Large zinc exposure can interfere with magnesium uptake.","subject":{"id":"9f823444-e2dd-5e16-9440-1bf2f62e8bdf","slug":"zinc-sulfate","display_name":"Zinc sulfate","entity_type_key":"chemical_species"},"object":{"id":"1423c5f4-b9c1-52ed-9a82-19e5aeece6cb","slug":"intestinal-magnesium-absorption","display_name":"Intestinal magnesium absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0c44af2c-e4b8-5686-8a7f-fd456c9ee08a","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-high-zinc-lowers-absorption-event","event_type":"observed_intervention","label":"Large zinc exposure can interfere with magnesium uptake.","description":"High-dose supplemental zinc reduced measured Mg absorption in the pooled metabolic-balance groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"administered_element","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"affected_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9f823444-e2dd-5e16-9440-1bf2f62e8bdf","slug":"zinc-sulfate","display_name":"Zinc sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"1423c5f4-b9c1-52ed-9a82-19e5aeece6cb","slug":"intestinal-magnesium-absorption","display_name":"Intestinal magnesium absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc -> magnesium availability; calcium intake recorded as context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Adult men; three dietary calcium strata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"142 mg Zn/day as sulfate; calcium 230, 500 or 800 mg/day. Only the 500-mg stratum individually significant; pooled groups significant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"142 mg zinc/day is a high experimental exposure; ordinary food zinc effects and a shared transporter were not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Large zinc exposure can interfere with magnesium uptake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human intestinal absorption and metabolic balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6bc57337-b37c-516b-b1ed-aad1b211839b","evidence_kind":"source_excerpt","locator":"Lines 1577-1588","start_line":1577,"end_line":1588,"excerpt":"### mg-high-zinc-lowers-absorption\nHigh-dose supplemental zinc reduced measured Mg absorption in the pooled metabolic-balance groups.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Large zinc exposure can interfere with magnesium uptake.\norganism: Homo sapiens\ntissue_or_cell_type: Human intestinal absorption and metabolic balance\nexperimental_model: Adult men; three dietary calcium strata.\nlimitations: 142 mg zinc/day is a high experimental exposure; ordinary food zinc effects and a shared transporter were not established.\ncross_nutrient: Zinc -> magnesium availability; calcium intake recorded as context.\nexposure: 142 mg Zn/day as sulfate; calcium 230, 500 or 800 mg/day. Only the 500-mg stratum individually significant; pooled groups significant.\n[mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438","model_system":"Adult men; three dietary calcium strata.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}