Component

Whole-body magnesium balance

Independent biological entity. Read linked claims for experimental scope and context.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Higher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls.

    Calcium → Whole-body magnesium balance source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Calcium -> magnesium balance: a bounded null interaction.
    experimental_model
    Randomized crossover; Mg isotope kinetics.
    exposure
    Calcium 800 versus 1800 mg/day; Mg intakes about 305 versus 286 mg/day.
    limitations
    Very small and population-specific; a null result is not equivalence for all intakes or ages.
    nutrient_topic
    Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
    organism
    Homo sapiens
    plain_language
    Calcium and magnesium do not always compete enough to change measured balance.
    primary_references
    [mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710
    tissue_or_cell_type
    Human whole-body Mg isotope kinetics

    Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1615–1626

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover; Mg isotope kinetics. · source_derived_draft · unverified_draft

    ### mg-high-calcium-no-kinetic-difference Higher calcium intake did not significantly alter Mg absorption, excretion or modeled balance in five adolescent girls. Condition category: normal nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcium and magnesium do not always compete enough to change measured balance. organism: Homo sapiens tissue_or_cell_type: Human whole-body Mg isotope kinetics experimental_model: Randomized crossover; Mg isotope kinetics. limitations: Very small and population-specific; a null result is not equivalence for all intakes or ages. cross_nutrient: Calcium -> magnesium balance: a bounded null interaction. exposure: Calcium 800 versus 1800 mg/day; Mg intakes about 305 versus 286 mg/day. [mg-sojka1997] Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake (1997). https://pubmed.ncbi.nlm.nih.gov/9277559/ DOI: 10.1152/ajpregu.1997.273.2.r710
    Complete structured claim and evidence

  2. The pooled high-zinc groups also had lower Mg balance.

    Zinc sulfate → Whole-body magnesium balance source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Zinc/Mg intake balance; exposure-dependent.
    experimental_model
    Same adult metabolic-balance experiment.
    limitations
    Not a molecular transporter competition assay or evidence that every zinc dose depletes Mg.
    nutrient_topic
    Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
    organism
    Homo sapiens
    plain_language
    Absorption interference was accompanied by a change in net magnesium balance.
    primary_references
    [mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438
    tissue_or_cell_type
    Human intestinal absorption and metabolic balance

    Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1590–1600

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Same adult metabolic-balance experiment. · source_derived_draft · unverified_draft

    ### mg-high-zinc-lowers-balance The pooled high-zinc groups also had lower Mg balance. Condition category: normal nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Absorption interference was accompanied by a change in net magnesium balance. organism: Homo sapiens tissue_or_cell_type: Human intestinal absorption and metabolic balance experimental_model: Same adult metabolic-balance experiment. limitations: Not a molecular transporter competition assay or evidence that every zinc dose depletes Mg. cross_nutrient: Zinc/Mg intake balance; exposure-dependent. [mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438
    Complete structured claim and evidence

  3. Magnesium balance became negative at 118 mg/day magnesium, and changing boron intake did not obviously modify the overall response to magnesium deprivation.

    Boron → Whole-body magnesium balance source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/15724868.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24", "start_char": 0, "end_char": 2138, "text_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24"}
    experimental_model
    Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women
    exposure
    Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods
    limitations
    Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human
    plain_language
    This study does not support a claim that boron makes up for inadequate magnesium.
    primary_references
    [boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/
    tissue_or_cell_type
    Mineral balance and endocrine measurements
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 742–753

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women · source_derived_draft · unverified_draft

    ### boron-magnesium-balance-no-rescue Magnesium balance became negative at 118 mg/day magnesium, and changing boron intake did not obviously modify the overall response to magnesium deprivation. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: This study does not support a claim that boron makes up for inadequate magnesium. organism: Human tissue_or_cell_type: Mineral balance and endocrine measurements experimental_model: Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women limitations: Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium. exposure: Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods evidence_span: {"source_cache": "artifacts/boron-research/15724868.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24", "start_char": 0, "end_char": 2138, "text_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24"} [boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/
    Complete structured claim and evidence

  4. The higher-boron diet increased apparent magnesium balance in vitamin-D-deprived rats, with substantial variability.

    Boron → Whole-body magnesium balance source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/7889882.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a", "start_char": 0, "end_char": 1082, "text_sha256": "f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a"}
    experimental_model
    Vitamin-D-deficient rat feeding experiment
    exposure
    Dietary boron 2.72 versus 0.16 ppm with vitamin D deprivation
    limitations
    Apparent balances were variable. Previous vitamin D stores were a proposed explanation of variability, not proof that boron inhibits a vitamin D enzyme.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Rat
    plain_language
    The animal experiment measured greater apparent retention of magnesium under the higher-boron diet.
    primary_references
    [boron-p7889882] Effects of dietary boron in rats fed a vitamin D-deficient diet. (1994). https://pubmed.ncbi.nlm.nih.gov/7889882/ DOI: 10.1289/ehp.94102s755
    tissue_or_cell_type
    Whole-body apparent mineral balance
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 820–831

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Vitamin-D-deficient rat feeding experiment · source_derived_draft · unverified_draft

    ### boron-rat-magnesium-balance The higher-boron diet increased apparent magnesium balance in vitamin-D-deprived rats, with substantial variability. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The animal experiment measured greater apparent retention of magnesium under the higher-boron diet. organism: Rat tissue_or_cell_type: Whole-body apparent mineral balance experimental_model: Vitamin-D-deficient rat feeding experiment limitations: Apparent balances were variable. Previous vitamin D stores were a proposed explanation of variability, not proof that boron inhibits a vitamin D enzyme. exposure: Dietary boron 2.72 versus 0.16 ppm with vitamin D deprivation evidence_span: {"source_cache": "artifacts/boron-research/7889882.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a", "start_char": 0, "end_char": 1082, "text_sha256": "f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a"} [boron-p7889882] Effects of dietary boron in rats fed a vitamin D-deficient diet. (1994). https://pubmed.ncbi.nlm.nih.gov/7889882/ DOI: 10.1289/ehp.94102s755
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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