{"id":"bf6ea6c2-898c-58fc-abb8-16da0513d76a","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-magnesium-balance-no-rescue","predicate":"did_not_obviously_rescue","statement":"Magnesium balance became negative at 118 mg/day magnesium, and changing boron intake did not obviously modify the overall response to magnesium deprivation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7042936f-8f07-5d98-9f04-ccf2ef2a1aea","mechanism_event_label":"This study does not support a claim that boron makes up for inadequate magnesium.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"2531a929-cde5-5ffa-aa2d-ffa9f2bee029","slug":"magnesium-balance","display_name":"Whole-body magnesium balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7042936f-8f07-5d98-9f04-ccf2ef2a1aea","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-magnesium-balance-no-rescue-event","event_type":"observed_intervention","label":"This study does not support a claim that boron makes up for inadequate magnesium.","description":"Magnesium balance became negative at 118 mg/day magnesium, and changing boron intake did not obviously modify the overall response to magnesium deprivation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"restricted_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2531a929-cde5-5ffa-aa2d-ffa9f2bee029","slug":"magnesium-balance","display_name":"Whole-body magnesium balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/15724868.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\", \"start_char\": 0, \"end_char\": 2138, \"text_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This study does not support a claim that boron makes up for inadequate magnesium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mineral balance and endocrine measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"949a77bc-1a6a-56e1-8886-80fea4eb909b","evidence_kind":"source_excerpt","locator":"Lines 742-753","start_line":742,"end_line":753,"excerpt":"### boron-magnesium-balance-no-rescue\nMagnesium balance became negative at 118 mg/day magnesium, and changing boron intake did not obviously modify the overall response to magnesium deprivation.\nCondition category: nutrient_deficiency\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This study does not support a claim that boron makes up for inadequate magnesium.\norganism: Human\ntissue_or_cell_type: Mineral balance and endocrine measurements\nexperimental_model: Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women\nlimitations: Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium.\nexposure: Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods\nevidence_span: {\"source_cache\": \"artifacts/boron-research/15724868.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\", \"start_char\": 0, \"end_char\": 2138, \"text_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\"}\n[boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/","model_system":"Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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