{"id":"850bc18c-241b-5b5f-8efc-0f08688a1ea2","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-high-zinc-lowers-balance","predicate":"high_intake_reduces","statement":"The pooled high-zinc groups also had lower Mg balance.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8bc6bb5b-610a-5910-9a38-0143f9a12fe2","mechanism_event_label":"Absorption interference was accompanied by a change in net magnesium balance.","subject":{"id":"9f823444-e2dd-5e16-9440-1bf2f62e8bdf","slug":"zinc-sulfate","display_name":"Zinc sulfate","entity_type_key":"chemical_species"},"object":{"id":"2531a929-cde5-5ffa-aa2d-ffa9f2bee029","slug":"magnesium-balance","display_name":"Whole-body magnesium balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8bc6bb5b-610a-5910-9a38-0143f9a12fe2","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-high-zinc-lowers-balance-event","event_type":"observed_intervention","label":"Absorption interference was accompanied by a change in net magnesium balance.","description":"The pooled high-zinc groups also had lower Mg balance.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"affected_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f823444-e2dd-5e16-9440-1bf2f62e8bdf","slug":"zinc-sulfate","display_name":"Zinc sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2531a929-cde5-5ffa-aa2d-ffa9f2bee029","slug":"magnesium-balance","display_name":"Whole-body magnesium balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc/Mg intake balance; exposure-dependent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same adult metabolic-balance experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a molecular transporter competition assay or evidence that every zinc dose depletes Mg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Absorption interference was accompanied by a change in net magnesium balance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human intestinal absorption and metabolic balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ac689e21-effb-52a5-9ac6-3d55860c1719","evidence_kind":"source_excerpt","locator":"Lines 1590-1600","start_line":1590,"end_line":1600,"excerpt":"### mg-high-zinc-lowers-balance\nThe pooled high-zinc groups also had lower Mg balance.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Absorption interference was accompanied by a change in net magnesium balance.\norganism: Homo sapiens\ntissue_or_cell_type: Human intestinal absorption and metabolic balance\nexperimental_model: Same adult metabolic-balance experiment.\nlimitations: Not a molecular transporter competition assay or evidence that every zinc dose depletes Mg.\ncross_nutrient: Zinc/Mg intake balance; exposure-dependent.\n[mg-spencer1994] Inhibitory effects of zinc on magnesium balance and magnesium absorption in man (1994). https://pubmed.ncbi.nlm.nih.gov/7836627/ DOI: 10.1080/07315724.1994.10718438","model_system":"Same adult metabolic-balance experiment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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