Component

Mouse aryl hydrocarbon receptor / Ahr

Mouse aryl hydrocarbon receptor / Ahr. Species, exposure and limitations are retained in each linked claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The identified 2-oxo-DIM product showed greater potency and efficacy than parent DIM in a Hepa1 AhR reporter assay.

    2-Oxo-DIM / 3-((1H-indol-3-yl)methyl)indolin-2-one → Mouse aryl hydrocarbon receptor / Ahr source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"}
    experimental_model
    Human serial plasma/urine mass spectrometry and reporter assays
    exposure
    Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule
    limitations
    Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Seven adults; mouse Hepa1 reporter cells
    plain_language
    A metabolite can signal more strongly than the compound that produced it.
    primary_references
    [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    tissue_or_cell_type
    DIM metabolism and metabolite signaling

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 246–257

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human serial plasma/urine mass spectrometry and reporter assays · source_derived_draft · unverified_draft

    ### dim-dim-metabolite-ahr The identified 2-oxo-DIM product showed greater potency and efficacy than parent DIM in a Hepa1 AhR reporter assay. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A metabolite can signal more strongly than the compound that produced it. organism: Seven adults; mouse Hepa1 reporter cells tissue_or_cell_type: DIM metabolism and metabolite signaling experimental_model: Human serial plasma/urine mass spectrometry and reporter assays limitations: Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response. exposure: Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule evidence_span: {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"} [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    Complete structured claim and evidence

  2. Purified kynurenine-derived TEACOPs activated mouse AHR at low picomolar concentrations in the reported assays.

    Kynurenine-derived trace extended aromatic condensation products / TEACOPs → Mouse aryl hydrocarbon receptor / Ahr source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract and primary full text, Figure 1 and receptor constructs
    experimental_model
    Mouse AHR constructs in chemical pharmacology experiments.
    limitations
    Mouse receptor evidence must not be silently converted into a measured human physiological concentration.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    Tiny amounts of a derivative can change receptor signaling.
    primary_references
    Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 442–448

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse AHR constructs in chemical pharmacology experiments. · source_derived_draft · unverified_draft

    ## tryptophan-teacop-ahr Tiny amounts of a derivative can change receptor signaling. Purified kynurenine-derived TEACOPs activated mouse AHR at low picomolar concentrations in the reported assays. Model: Mouse AHR constructs in chemical pharmacology experiments. Limitations: Mouse receptor evidence must not be silently converted into a measured human physiological concentration. Evidence access: Primary abstract and primary full text, Figure 1 and receptor constructs Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Microbial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice.

    Indole-3-aldehyde → Mouse interleukin-22 / Il22 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse mucosal immunity and microbial metabolite experiments.
    limitations
    Not a direct human supplementation outcome.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    A microbial product connected the amino acid to an epithelial-defense cytokine.
    primary_references
    Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 474–480

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse mucosal immunity and microbial metabolite experiments. · source_derived_draft · unverified_draft

    ## tryptophan-aldehyde-ahr A microbial product connected the amino acid to an epithelial-defense cytokine. Microbial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice. Model: Mouse mucosal immunity and microbial metabolite experiments. Limitations: Not a direct human supplementation outcome. Evidence access: Primary abstract Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003
    Complete structured claim and evidence

  2. IL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study.

    Mouse interleukin-22 / Il22 → Mouse susceptibility to chemically induced colitis in tryptophan experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse fungal colonization and mucosal inflammation models.
    limitations
    This protective model does not establish a universally beneficial effect of sustained AHR or IL-22 activation.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    The downstream cytokine helped organize mucosal defense.
    primary_references
    Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 482–488

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse fungal colonization and mucosal inflammation models. · source_derived_draft · unverified_draft

    ## tryptophan-il22-protection The downstream cytokine helped organize mucosal defense. IL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study. Model: Mouse fungal colonization and mucosal inflammation models. Limitations: This protective model does not establish a universally beneficial effect of sustained AHR or IL-22 activation. Evidence access: Primary abstract Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003
    Complete structured claim and evidence

  3. Incubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity.

    L-Kynurenine → Kynurenine-derived trace extended aromatic condensation products / TEACOPs source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments.
    limitations
    Does not quantify TEACOP concentrations in human tumors or prove every kynurenine-associated effect is caused by these products.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    What forms from a metabolite in solution can matter more than the nominal starting compound.
    primary_references
    Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 434–440

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments. · source_derived_draft · unverified_draft

    ## tryptophan-teacop-formation What forms from a metabolite in solution can matter more than the nominal starting compound. Incubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity. Model: Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments. Limitations: Does not quantify TEACOP concentrations in human tumors or prove every kynurenine-associated effect is caused by these products. Evidence access: Primary abstract Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards