Component
Kynurenine-derived trace extended aromatic condensation products / TEACOPs
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Purified kynurenine-derived TEACOPs activated mouse AHR at low picomolar concentrations in the reported assays.
Experimental context and source evidence
- evidence_access
- Primary abstract and primary full text, Figure 1 and receptor constructs
- experimental_model
- Mouse AHR constructs in chemical pharmacology experiments.
- limitations
- Mouse receptor evidence must not be silently converted into a measured human physiological concentration.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- Tiny amounts of a derivative can change receptor signaling.
- primary_references
- Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 442–448
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse AHR constructs in chemical pharmacology experiments. · source_derived_draft · unverified_draft
## tryptophan-teacop-ahr Tiny amounts of a derivative can change receptor signaling. Purified kynurenine-derived TEACOPs activated mouse AHR at low picomolar concentrations in the reported assays. Model: Mouse AHR constructs in chemical pharmacology experiments. Limitations: Mouse receptor evidence must not be silently converted into a measured human physiological concentration. Evidence access: Primary abstract and primary full text, Figure 1 and receptor constructs Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631
Complete structured claim and evidence
What acts on it
Incubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments.
- limitations
- Does not quantify TEACOP concentrations in human tumors or prove every kynurenine-associated effect is caused by these products.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- What forms from a metabolite in solution can matter more than the nominal starting compound.
- primary_references
- Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 434–440
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments. · source_derived_draft · unverified_draft
## tryptophan-teacop-formation What forms from a metabolite in solution can matter more than the nominal starting compound. Incubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity. Model: Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments. Limitations: Does not quantify TEACOP concentrations in human tumors or prove every kynurenine-associated effect is caused by these products. Evidence access: Primary abstract Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.