{"id":"9a34d0ea-b876-5741-b9a9-cf2dfcc6b1c5","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-teacop-formation","predicate":"forms_active_trace_derivatives","statement":"Incubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d862aa14-5b46-59aa-9e51-b455eb90c0d6","mechanism_event_label":"What forms from a metabolite in solution can matter more than the nominal starting compound.","subject":{"id":"ce72cbd6-7077-5f23-a859-a8000a3f8194","slug":"kynurenine","display_name":"L-Kynurenine","entity_type_key":"small_molecule"},"object":{"id":"7246a7bc-469a-5269-b0fe-c8dd6c56fa9d","slug":"kynurenine-teacops","display_name":"Kynurenine-derived trace extended aromatic condensation products / TEACOPs","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"d862aa14-5b46-59aa-9e51-b455eb90c0d6","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-teacop-formation-event","event_type":"observed_relationship","label":"What forms from a metabolite in solution can matter more than the nominal starting compound.","description":"Incubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce72cbd6-7077-5f23-a859-a8000a3f8194","slug":"kynurenine","display_name":"L-Kynurenine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7246a7bc-469a-5269-b0fe-c8dd6c56fa9d","slug":"kynurenine-teacops","display_name":"Kynurenine-derived trace extended aromatic condensation products / TEACOPs","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"af2dbfd7-6b48-5f35-b6ff-15c0a1e24aa9","slug":"mouse-ahr","display_name":"Mouse aryl hydrocarbon receptor / Ahr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not quantify TEACOP concentrations in human tumors or prove every kynurenine-associated effect is caused by these products.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"What forms from a metabolite in solution can matter more than the nominal starting compound.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f24d48ea-ce4e-5e6d-a6ba-c88a82dd027d","evidence_kind":"source_excerpt","locator":"Lines 434-440","start_line":434,"end_line":440,"excerpt":"## tryptophan-teacop-formation\nWhat forms from a metabolite in solution can matter more than the nominal starting compound.\nIncubation or storage increased kynurenine-solution AHR potency by 100–1000-fold; isolated trace condensation products accounted for potent activity.\nModel: Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments.\nLimitations: Does not quantify TEACOP concentrations in human tumors or prove every kynurenine-associated effect is caused by these products.\nEvidence access: Primary abstract\nTrace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). · 2018 · https://pubmed.ncbi.nlm.nih.gov/29279331/ · DOI 10.1074/jbc.RA117.000631","model_system":"Chemical purification, synthesis and mouse-AHR reporter/ligand-pocket experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}