{"id":"98542cb2-822f-5b34-8172-44d8c1e3cf72","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-il22-protection","predicate":"reduces_inflammatory_susceptibility","statement":"IL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"83e8262a-409e-5f1f-8242-51e771fd43bd","mechanism_event_label":"The downstream cytokine helped organize mucosal defense.","subject":{"id":"7da9efbe-a654-57be-bfbd-6b5eba3794c8","slug":"mouse-il22","display_name":"Mouse interleukin-22 / Il22","entity_type_key":"cytokine"},"object":{"id":"8cb2bb35-537a-5db0-b138-94506b1303d1","slug":"mouse-trp-colitis-susceptibility","display_name":"Mouse susceptibility to chemically induced colitis in tryptophan experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"83e8262a-409e-5f1f-8242-51e771fd43bd","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-il22-protection-event","event_type":"observed_relationship","label":"The downstream cytokine helped organize mucosal defense.","description":"IL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7da9efbe-a654-57be-bfbd-6b5eba3794c8","slug":"mouse-il22","display_name":"Mouse interleukin-22 / Il22","entity_type_key":"cytokine"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8cb2bb35-537a-5db0-b138-94506b1303d1","slug":"mouse-trp-colitis-susceptibility","display_name":"Mouse susceptibility to chemically induced colitis in tryptophan experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3848aa02-353b-5f20-a28e-e424d6efdb8a","slug":"indole-3-aldehyde","display_name":"Indole-3-aldehyde","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"af2dbfd7-6b48-5f35-b6ff-15c0a1e24aa9","slug":"mouse-ahr","display_name":"Mouse aryl hydrocarbon receptor / Ahr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse fungal colonization and mucosal inflammation models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This protective model does not establish a universally beneficial effect of sustained AHR or IL-22 activation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The downstream cytokine helped organize mucosal defense.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f733706a-f394-5f9b-a281-9a1f8e2a2a80","evidence_kind":"source_excerpt","locator":"Lines 482-488","start_line":482,"end_line":488,"excerpt":"## tryptophan-il22-protection\nThe downstream cytokine helped organize mucosal defense.\nIL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study.\nModel: Mouse fungal colonization and mucosal inflammation models.\nLimitations: This protective model does not establish a universally beneficial effect of sustained AHR or IL-22 activation.\nEvidence access: Primary abstract\nTryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003","model_system":"Mouse fungal colonization and mucosal inflammation models.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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